PMID: 810520Oct 1, 1975

A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates

The Journal of Infectious Diseases
H B LevyJ Rice

Abstract

A comlex of polyriboinosinic-polyribocytidylic acid (poly I-poly C) with poly-L-lysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I-poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I-poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferon.

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Related Concepts

Anthropoidea
Cethylose
Pan troglodytes
Hydrolysis
Interferons
Macaca
Macaca mulatta
Poly I-C
Poly-(Alpha-L-Lysine)

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