A modular flow reactor for performing Curtius rearrangements as a continuous flow process

Organic & Biomolecular Chemistry
Marcus BaumannJason P Tierney

Abstract

The use of a mesofluidic flow reactor is described for performing Curtius rearrangement reactions of carboxylic acids in the presence of diphenylphosphoryl azide and trapping of the intermediate isocyanates with various nucleophiles.

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Citations

Jan 31, 2012·Journal of Medicinal Chemistry·Laia Malet-Sanz, Flavien Susanne
Jun 5, 2010·Organic Letters·Toby R LongPaul R Hanson
Dec 30, 2009·Organic Letters·Ananda HerathNicholas D P Cosford
Apr 19, 2008·Organic & Biomolecular Chemistry·Marcus BaumannChristopher D Smith
Mar 24, 2010·Chemical Communications : Chem Comm·Mark D HopkinSteven V Ley
Jul 11, 2009·Beilstein Journal of Organic Chemistry·Alessandro PalmieriIan R Baxendale
Jul 11, 2009·Beilstein Journal of Organic Chemistry·Johan C Brandt, Thomas Wirth
Jul 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcus BaumannKimberley A Roper
Mar 26, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ravendra SinghRohit Ramachandran
Jul 28, 2016·Chemical Society Reviews·M MovsisyanC V Stevens
Mar 20, 2010·Organic & Biomolecular Chemistry·Catherine F CarterSteven V Ley
May 8, 2010·Organic & Biomolecular Chemistry·Francesco VenturoniIan R Baxendale
Apr 23, 2010·Chemistry, an Asian Journal·Tahseen Razzaq, C Oliver Kappe
Jun 20, 2012·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Steven V Ley
Nov 19, 2014·Chemistry : a European Journal·Benjamin J DeadmanAnita R Maguire
Oct 2, 2015·Beilstein Journal of Organic Chemistry·Marcus Baumann, Ian R Baxendale
Oct 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kian DonnellyMarcus Baumann
Apr 10, 2015·ChemSusChem·Yoshinori OkunoKazuyoshi Takeda
Oct 21, 2010·Molecular Diversity·Marcus BaumannSteven V Ley
Dec 22, 2010·Chemical Communications : Chem Comm·Alexander G O'BrienPeter H Seeberger
Jul 29, 2011·Chemistry : a European Journal·Thomas O PainterJeffrey Aubé
Sep 4, 2013·Chemical Society Reviews·Julio C PastreSteven V Ley
Jan 16, 2014·Organic & Biomolecular Chemistry·Xiaolin ZongNing Jiao
Aug 17, 2018·Beilstein Journal of Organic Chemistry·Mrityunjay K SharmaAmol A Kulkarni
Feb 27, 2018·Organic & Biomolecular Chemistry·Arun K GhoshMargherita Brindisi
Mar 24, 2018·Nature Chemistry·David C BlakemoreAnthony Wood
Sep 12, 2008·Journal of Combinatorial Chemistry·Ian R BaxendaleAna-Florina Voica
Apr 9, 2021·Beilstein Journal of Organic Chemistry·Alexander LeslieMarcus Baumann
Oct 27, 2009·Organic Letters·Trine P PetersenTrond Ulven
Nov 7, 2012·The Journal of Organic Chemistry·Kim HuardRobert L Dow

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