A modular framework for multiscale multicellular spatial modeling of viral infection, immune response and drug therapy timing and efficacy in epithelial tissues: A multiscale model of viral infection in epithelial tissues.

BioRxiv : the Preprint Server for Biology
T J SegoJames A Glazier

Abstract

Development of predictive quantitative models of all aspects of COVID-19 is essential for rapidly understanding the causes of differing disease outcomes and vulnerabilities, suggesting drug and therapeutic targets, and designing optimized personalized interventions. Easy to implement, predictive multiscale modeling frameworks to integrate the wide variety of clinical and research datasets into actionable insights, which could inform therapeutic regime strategies are lacking. We present a multiscale, multicellular, spatiotemporal model of the infection of epithelial tissue by a generic virus, a simplified cellular immune response and viral and immune-induced tissue damage. Our initial model is built of modular components to allow it to be easily extended and adapted in a collaborative fashion to describe specific viral infections, tissue types and immune responses. The model allows us to define three parameter regimes: where viral infection coincides with a massive cytopathic effect, where the immune System rapidly controls the virus and where the immune System controls the virus but extensive tissue damage occurs. We use the model in a proof-of-concept application to evaluate a number of drug therapy concepts. Inhibition of vir...Continue Reading

Citations

May 27, 2021·Bulletin of Mathematical Biology·Ericka MochanG Bard Ermentrout

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.