A modular method to handle multiple time-dependent quantities in Monte Carlo simulations.

Physics in Medicine and Biology
J ShinB Faddegon

Abstract

A general method for handling time-dependent quantities in Monte Carlo simulations was developed to make such simulations more accessible to the medical community for a wide range of applications in radiotherapy, including fluence and dose calculation. To describe time-dependent changes in the most general way, we developed a grammar of functions that we call 'Time Features'. When a simulation quantity, such as the position of a geometrical object, an angle, a magnetic field, a current, etc, takes its value from a Time Feature, that quantity varies over time. The operation of time-dependent simulation was separated into distinct parts: the Sequence samples time values either sequentially at equal increments or randomly from a uniform distribution (allowing quantities to vary continuously in time), and then each time-dependent quantity is calculated according to its Time Feature. Due to this modular structure, time-dependent simulations, even in the presence of multiple time-dependent quantities, can be efficiently performed in a single simulation with any given time resolution. This approach has been implemented in TOPAS (TOol for PArticle Simulation), designed to make Monte Carlo simulations with Geant4 more accessible to both...Continue Reading

References

Jan 1, 2000·Physics in Medicine and Biology·F Verhaegen, I J Das
Apr 28, 2001·Physics in Medicine and Biology·P J KeallR Mohan
Aug 9, 2003·Medical Physics·H Paganetti, B Gottschalk
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Aug 15, 2008·Physics in Medicine and Biology·Harald PaganettiMartijn Engelsman

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Citations

Nov 26, 2015·Technology in Cancer Research & Treatment·Joost Mathijs VerburgHarald Paganetti
Apr 27, 2018·Physics in Medicine and Biology·J Ramos-MéndezB Faddegon
Jul 9, 2014·Physics in Medicine and Biology·Mauro TestaHarald Paganetti
Jun 11, 2015·Physics in Medicine and Biology·J Ramos-MéndezB Faddegon
Jun 11, 2015·Physics in Medicine and Biology·Lisa PolsterHarald Paganetti
Jun 11, 2015·Physics in Medicine and Biology·J Ramos MéndezB Faddegon
Aug 13, 2021·Physics in Medicine and Biology·Hyojun ParkChul Hee Min

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