A modulation of the anaphylactic basophil histamine release by selective H2 histamine agonists

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W KazimierczakK Bańkowska

Abstract

Two selective H2-histamine agonists, dimaprit and impromidine, have been tested for their action on histamine release from human basophils and rat mast cells. IgE-mediated basophil histamine release was inhibited by stimulation of histamine H2-receptors. However, differences between the actions of both dimaprit and impromidine were noticed. Both impromidine and dimaprit had no specific effect on 48/80-induced histamine release from rat mast cells, although the latter in higher concentrations either slightly increased spontaneous histamine release or non-specifically inhibited compound 48/80-induced release. The results are consistent with the view that activation of adenylate cyclase via H2-histamine receptors might be an important regulatory mechanism of histamine release from human basophils but not from rat mast cells.

Citations

Apr 29, 2014·The Journal of Allergy and Clinical Immunology·Ilkka T HarvimaMarcus Maurer
Aug 1, 1984·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·T TsuchiyaA Hang
Mar 1, 1982·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·G Künzel
Feb 13, 2018·Immunological Reviews·Gilda VarricchiBernhard F Gibbs

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