A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
N Ruth ZearfossJoel D Richter

Abstract

Cytoplasmic polyadenylation element binding protein 1 (CPEB-1) resides at postsynaptic sites in hippocampal neurons in which it controls polyadenylation-induced translation. CPEB-1 knock-out (KO) mice display defects in some forms of synaptic plasticity and hippocampal-dependent memories. To identify CPEB-1-regulated mRNAs, we used proteomics to compare polypeptides in wild-type (WT) and CPEB-1 KO hippocampus. Growth hormone (GH) was reduced in the KO hippocampus, as were the GH signaling molecules phospho-JAK2 and phospho-STAT3. GH mRNA and pre-mRNA were reduced in the KO hippocampus, suggesting that CPEB-1 controls GH transcription. The transcription factor c-Jun, which binds the GH promoter, was also reduced in the KO hippocampus, as was its ability to coimmunoprecipitate chromatin containing the GH promoter. CPEB-1 binds c-Jun 3' untranslated region CPEs in vitro and coimmunoprecipitates c-Jun RNA in vivo. GH induces long-term potentiation (LTP) when applied to hippocampal slices from WT and CPEB-1 KO mice, but the magnitude of LTP induced by GH in KO mice is reduced. Pretreatment with GH did not reverse the LTP deficit observed in KO mice after theta-burst stimulation (TBS). Cordycepin, an inhibitor of polyadenylation, dis...Continue Reading

References

Aug 6, 1998·European Journal of Biochemistry·S MoutoussamyJ Finidori
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A TenenbaumJ D Keene
Jun 13, 2001·Oncogene·F MaciánA Rao
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·J D Richter
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·R Mendez, J D Richter
Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·J Herrington, C Carter-Su
Aug 10, 2001·Cellular Signalling·T ZhuP E Lobie
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·M R ViannaI Izquierdo
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Scott A TenenbaumJack D Keene
Jun 24, 2003·Neuron·María Eugenia Pedreira, Héctor Maldonado
Jul 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Martin TheisEric R Kandel
Aug 30, 2003·Nature Neuroscience·Mollie K MeffertDavid Baltimore
Oct 15, 2003·Neuron·Oswald Steward, Erin M Schuman
Feb 27, 2004·Physiology & Behavior·B A Kinney-ForsheeA Bartke
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Coleen M AtkinsThomas R Soderling
Jun 25, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edwin SantiniGregory J Quirk
Sep 29, 2004·Neuron·Raymond J KelleherSusumu Tonegawa
Feb 19, 2005·Neurobiology of Aging·Liou Y SunAndrzej Bartke
May 11, 2005·Journal of Neurobiology·Michael A Sutton, Erin M Schuman
Nov 30, 2005·Molecular and Cellular Biology·Quiping CaoJoel D Richter
Jan 31, 2006·Neurobiology of Disease·Alice S Chen-PlotkinJang-Ho J Cha
Feb 3, 2006·Learning & Memory·Joanne Berger-SweeneyJoel D Richter
Feb 17, 2006·Journal of Neurophysiology·Ghada S Mahmoud, Lawrence M Grover
Apr 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christine P DonahueTracey J Shors
Jun 23, 2006·Nature Reviews. Neuroscience·Arvind GovindarajanSusumu Tonegawa
Oct 21, 2006·Molecular Cell·Jong Heon Kim, Joel D Richter
Oct 17, 2007·Genes & Development·Jong Heon Kim, Joel D Richter

❮ Previous
Next ❯

Citations

Oct 16, 2013·Molecular Psychiatry·R M MeyerK A Goosens
Jun 6, 2012·Nature Structural & Molecular Biology·Laure WeillRaúl Méndez
Nov 27, 2009·The Journal of Biological Chemistry·Ying Ying WongCornelia H de Moor
Aug 10, 2010·The Journal of Biological Chemistry·Christos GkogkasMauro Costa-Mattioli
Mar 27, 2009·Molecular Human Reproduction·Pulak R MannaDouglas M Stocco
May 4, 2011·Molecular and Cellular Biology·Rachel Groppo, Joel D Richter
Mar 20, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eunyoung KimTodd L Green
Jun 26, 2014·Neuroscience Bulletin·Epaminondas Doxakis
Jul 30, 2014·Annual Review of Cell and Developmental Biology·Maria IvshinaJoel D Richter
Oct 22, 2013·Nature Medicine·Tsuyoshi UdagawaJoel D Richter
May 1, 2012·Ageing Research Reviews·Gonzalo Fernández-Miranda, Raúl Méndez
Feb 14, 2012·Ageing Research Reviews·Kiyoshi MasudaKazuhito Rokutan
May 1, 2010·Current Opinion in Neurobiology·Wayne S Sossin, Jean-Claude Lacaille
Jun 19, 2013·Wiley Interdisciplinary Reviews. RNA·Amanda CharlesworthCornelia H de Moor
Jul 24, 2010·Molecular Reproduction and Development·Melanie C MacNicol, Angus M MacNicol
May 20, 2014·General and Comparative Endocrinology·Carlos ArámburoSteve Harvey
Sep 10, 2015·Nature Reviews. Neuroscience·Joel D RichterEric Klann
May 31, 2011·Biochemical and Biophysical Research Communications·Ki Chan KimChan Young Shin
Oct 23, 2012·Neuron·Sebastian KrüttnerKrystyna Keleman
Nov 19, 2010·Cell Cycle·Xiaokan ZhangFrida E Kleiman
Sep 24, 2013·JAK-STAT·Celine S NicolasStephane Peineau
Apr 29, 2015·Pharmacogenomics·Massimo UbaldiGary Hardiman
Dec 12, 2012·Cell Metabolism·Aparna Oruganty-DasJoel D Richter
Jul 14, 2011·Acta Biochimica Et Biophysica Sinica·John R Sinnamon, Kevin Czaplinski
Dec 30, 2015·PloS One·João Sollari LopesRui F Oliveira
Apr 9, 2017·Hormones and Behavior·Amrita BasuJohn J Kopchick
Jun 19, 2018·Wiley Interdisciplinary Reviews. RNA·Rafailia A A Beta, Nikolaos A A Balatsos
Dec 3, 2014·Molecular and Cellular Biology·Maria IvshinaJoel D Richter
Apr 17, 2013·Physiological Reviews·Andrzej BartkeValter Longo
Jul 18, 2019·Journal of Neurochemistry·Yuan-Yuan HanChu-Hua Li
Jun 15, 2018·Oncotarget·Béatrice JollesOlivier Jean-Jean
Jul 19, 2013·Endocrinology·Paul J Bonthuis, Emilie F Rissman
Nov 30, 2016·Translational Psychiatry·B GisabellaK A Goosens
Aug 8, 2018·International Journal of Molecular Sciences·Stylianos RavanidisEpaminondas Doxakis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.