PMID: 9187656Jun 1, 1997Paper

A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone

Nature Structural Biology
C ProdromouL H Pearl

Abstract

Hsp90 is a highly specific chaperone for many signal transduction proteins, including steroid hormone receptors and a broad range of protein kinases. The crystal structure of the N-terminal domain of the yeast Hsp90 reveals a dimeric structure based on a highly twisted sixteen stranded beta-sheet, whose topology suggests a possible 30-domain-swapped structure for the intact Hsp90 dimer. The opposing faces of the beta-sheets in the dimer define a potential peptide-binding cleft, suggesting that the N-domain may serve as a molecular 'clamp' in the binding of ligand proteins to Hsp90.

References

Jul 9, 1992·Nature·H WiechU Jakob
Jul 12, 1990·Nature·M S BoguskiM Goebl
Mar 1, 1991·Acta Crystallographica. Section A, Foundations of Crystallography·T A JonesM Kjeldgaard
Jan 1, 1986·Current Topics in Microbiology and Immunology·J S Brugge
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H OppermannJ M Bishop
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C RadanyiE E Baulieu
Apr 1, 1995·The Biochemical Journal·K Hoffmann, R E Handschumacher
Jul 1, 1995·Molecular and Cellular Biology·D F Nathan, S Lindquist
Dec 1, 1995·Molecular and Cellular Biology·D F SmithR A Rimerman
Dec 1, 1995·Protein Science : a Publication of the Protein Society·M J BennettD Eisenberg
Jun 28, 1996·The Journal of Biological Chemistry·D Portilla, G Dai
Dec 6, 1996·Science·S BoseJ Buchner
Nov 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·E A Merritt, M E Murphy
Sep 1, 1995·Acta Crystallographica. Section D, Biological Crystallography·D T MitchellM L Hackert

❮ Previous
Next ❯

Citations

Mar 17, 2004·Biochimica Et Biophysica Acta·Amere Subbarao SreedharPéter Csermely
Mar 31, 1998·Current Opinion in Structural Biology·J M Berger
Feb 19, 2000·Current Opinion in Structural Biology·L H Pearl, C Prodromou
Jun 24, 2000·Bioorganic & Medicinal Chemistry Letters·S D KudukS J Danishefsky
May 26, 1999·Bioorganic & Medicinal Chemistry Letters·S D KudukS J Danishefsky
May 14, 1999·Trends in Biochemical Sciences·J Buchner
Jan 19, 2000·Trends in Biochemical Sciences·R Dutta, M Inouye
Apr 4, 2000·Current Opinion in Microbiology·M E Gottesman, W A Hendrickson
Mar 19, 2011·Quarterly Reviews of Biophysics·Kristin A KrukenbergDavid A Agard
Jun 10, 2010·Nature Reviews. Molecular Cell Biology·Mikko TaipaleSusan Lindquist
Jun 1, 1997·Nature Structural Biology·A Joachimiak
Mar 10, 2001·The Biochemical Journal·T K NemotoK Tanaka
Apr 12, 2001·European Journal of Biochemistry·C GarnierV Peyrot
Apr 12, 2001·European Journal of Biochemistry·M MinamiY Minami
May 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Giorgio ColomboGennady Verkhivker
Feb 1, 2011·The Journal of Biological Chemistry·Lester Pullen, Daniel N Bolon
Jul 23, 2004·Anti-cancer Drugs·Jason Beliakoff, Luke Whitesell
Oct 2, 2008·Journal of the Royal Society, Interface·Aixia YanW Graham Richards
Jul 21, 1998·Annals of the New York Academy of Sciences·I YaharaY Miyata
Aug 28, 2012·Applied and Environmental Microbiology·Cheng-Zhu WuYoung-Soo Hong
Jan 5, 2002·Journal of Virology·Jan-Jong HungWen Chang
Aug 11, 2000·Molecular and Cellular Biology·P T Tran, R M Liskay
Jun 8, 2006·Annual Review of Biochemistry·Laurence H Pearl, Chrisostomos Prodromou
Mar 6, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshihiko Miyata
Feb 24, 2001·Cell Stress & Chaperones·S Basu, P K Srivastava
Mar 25, 2006·Future Oncology·Chengkai Dai, Luke Whitesell
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·D F NathanS Lindquist
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·P T TranR M Liskay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.