PMID: 7538176Jun 1, 1995Paper

A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion

Journal of Virology
C H ChenM L Greenberg

Abstract

We have previously reported that synthetic peptides representing the leucine zipper domain (DP107) and a second putative helical domain (DP178) of human immunodeficiency virus type 1 (HIV-1) gp41 exhibit potent anti-HIV activity. In this study we have used soluble recombinant forms of gp41 to provide evidence that the DP178 peptide and the DP178 region of gp41 associate with a distal site on the gp41 transmembrane protein whose interactive structure is influenced by the leucine zipper (DP107) motif. We also observed that a single coiled-coil-disrupting mutation in the leucine zipper domain transformed the recombinant gp41 protein from an inactive to an active inhibitor of HIV-1 fusion and infectivity, which may be related to that finding. We speculate that this transformation results from liberation of the potent DP178-related sequence from a molecular clasp with a leucine zipper, DP107, determinant. The results are discussed in the context of two distinct conformations for the gp41 molecule and possible involvement of these two domains in structural transitions associated with HIV-1-mediated fusion. The results are also interpreted to suggest that the anti-HIV activity of the various gp41 derivatives (peptides and recombinant ...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C WildT Matthews
Aug 1, 1991·The Journal of Experimental Medicine·Q J Sattentau, J P Moore
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·T K HartP J Bugelski
Jan 1, 1990·Annual Review of Physiology·J M White
Jun 1, 1990·AIDS Research and Human Retroviruses·E L DelwartT Gilmore
Aug 1, 1989·AIDS Research and Human Retroviruses·W R GallaherR C Montelaro
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T J MatthewsD P Bolognesi
Jan 1, 1987·Annual Review of Biochemistry·D C Wiley, J J Skehel
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·C T WildT J Matthews
Nov 1, 1993·AIDS Research and Human Retroviruses·C WildT Matthews
Sep 9, 1993·Nature·S JiangA R Neurath
Sep 15, 1993·Biochemical and Biophysical Research Communications·S JiangA R Neurath

❮ Previous
Next ❯

Citations

Dec 1, 1995·Nature Structural Biology·M LuP S Kim
May 22, 1997·Nature·W WeissenhornD C Wiley
Dec 10, 1999·Molecular Biology of the Cell·D H KingsleyJ Zimmerberg
Jan 12, 2001·AIDS Research and Human Retroviruses·C H ChenT J Matthews
Jun 8, 2001·Annual Review of Biochemistry·D M Eckert, P S Kim
Sep 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·John P Moore, Robert W Doms
Sep 16, 2004·The Journal of Membrane Biology·F S Cohen, G B Melikyan
Feb 1, 2007·AIDS Research and Human Retroviruses·Li HuangChin Ho Chen
Aug 23, 2008·Medicinal Research Reviews·Keduo QianKuo-Hsiung Lee
Mar 13, 2013·Protein & Cell·Yuanxi KangZhiwei Chen
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·K TanM Lu
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·D C ChanP S Kim
Nov 30, 2002·Expert Opinion on Investigational Drugs·Ray Y ChenMichael S Saag
Oct 12, 2000·The Journal of Biological Chemistry·Y KligerY Shai
Apr 23, 2004·Expert Opinion on Therapeutic Targets·Brian Tomkowicz, Ronald G Collman
May 30, 2003·The New England Journal of Medicine·J Michael Kilby, Joseph J Eron
Mar 10, 2001·AIDS Research and Human Retroviruses·P W MobleyL M Gordon
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·C B ZhuC H Chen
Mar 20, 2004·Nature Reviews. Drug Discovery·Tom MatthewsDani Bolognesi
Mar 13, 2003·Molecular Biology of the Cell·Ruben M MarkosyanGrigory B Melikyan
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·C M CarrP S Kim
Mar 25, 2008·Protein Science : a Publication of the Protein Society·John J DwyerMary K Delmedico
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·W WeissenhornD C Wiley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.