A molecular fluorescent dye for specific staining and imaging of RNA in live cells: a novel ligand integration from classical thiazole orange and styryl compounds

Chemical Communications : Chem Comm
Yu-Jing LuCheuk-Fai Chow

Abstract

A new RNA-selective fluorescent dye integrated with a thiazole orange and a p-(methylthio)styryl moiety shows better nucleolus RNA staining and imaging performance in live cells than the commercial stains. It also exhibits excellent photostability, cell tolerance, and counterstain compatibility with 4',6-diamidino-2-phenylindole for specific RNA-DNA colocalization in bioassays.

References

Nov 1, 1986·Cytometry·L G LeeL A Chiu
May 9, 1998·Science·A M FeminoR H Singer
Jul 21, 1998·Science·R Y Tsien, A Miyawaki
Nov 11, 1998·Molecular Cell·E BertrandR M Long
Dec 4, 2002·Nature Reviews. Molecular Cell Biology·Jin ZhangRoger Y Tsien
Jan 25, 2003·Methods : a Companion to Methods in Enzymology·Roeland W DirksHans J Tanke
Apr 5, 2003·Science·David J Stephens, Victoria J Allan
Aug 23, 2003·Chemical Communications : Chem Comm·Jae Wook LeeYoung-Tae Chang
Feb 14, 2004·Science·Amin RustomHans-Hermann Gerdes
Nov 24, 2004·Angewandte Chemie·Qian LiYoung-Tae Chang
Jan 7, 2005·Nature·Jens S AndersenMatthias Mann
Apr 6, 2005·Nucleic Acids Research·Musa M MhlangaSanjay Tyagi
Aug 2, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Awtar Krishan, Payal D Dandekar
Aug 6, 2005·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Robert M MartinM Cristina Cardoso
Jun 24, 2006·Chemistry & Biology·Qian LiYoung-Tae Chang
Aug 21, 2007·Chembiochem : a European Journal of Chemical Biology·Qian LiYoung-Tae Chang
Jan 12, 2010·Chemical Communications : Chem Comm·Alexandro MembrinoLuigi E Xodo
Jan 13, 2010·Chemical Communications : Chem Comm·Suihan FengYoung-Tae Chang
Mar 25, 2010·Biochemistry·Irit LubitzAlexander Kotlyar
Apr 24, 2010·Organic & Biomolecular Chemistry·Masayuki TeraKazuo Nagasawa
Nov 26, 2010·Nature Chemistry·Sebastian MüllerShankar Balasubramanian
Mar 25, 2011·Chemical Communications : Chem Comm·Yu-Jing LuKwok-Yin Wong
Feb 22, 2012·Nucleic Acids Research·Anthony Bugaut, Shankar Balasubramanian
Dec 15, 2012·Angewandte Chemie·Mehran NikanShankar Balasubramanian
Jan 26, 2013·Chemical Society Reviews·Dik-Lung MaChung-Hang Leung
Feb 21, 2013·Nature Chemistry·Giulia BiffiShankar Balasubramanian
Dec 21, 2013·Analytical Chemistry·Bing JinDihua Shangguan
Dec 24, 2013·Journal of the American Chemical Society·Jing LiuWei Guo
Feb 11, 2014·Nucleic Acids Research·Amandine Renaud de la FaverieJean-Louis Mergny
May 21, 2014·Chemical Communications : Chem Comm·Jin-Wu YanZhi-Shu Huang
Aug 22, 2014·Nature Chemistry·Alan D FaulknerPeter Scott
Sep 2, 2014·Chemical Communications : Chem Comm·Shuo-Bin ChenZhi-Shu Huang
Oct 23, 2014·Chemical Communications : Chem Comm·Liang GongRu-Qin Yu
Jan 9, 2015·Biosensors & Bioelectronics·Bingjiang ZhouPengfei Wang
Feb 26, 2015·Chemical Communications : Chem Comm·Chaesun HongDong-Eun Kim
Feb 27, 2015·Chemical Communications : Chem Comm·Achikanath C Bhasikuttan, Jyotirmayee Mohanty

❮ Previous
Next ❯

Citations

Jan 13, 2016·Organic & Biomolecular Chemistry·Sivakalai MayakrishnanParamasivan Thirumalai Perumal
Aug 23, 2016·Nature Cell Biology·Shani DrorCarmit Levy
Mar 23, 2017·Journal of Extracellular Vesicles·Bogdan MateescuEsther N M Nolte-'t Hoen
Feb 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pallavi ChilkaBhaskar Datta
Nov 17, 2017·Organic & Biomolecular Chemistry·Bahareh ShirinfarNisar Ahmed
Oct 13, 2020·Nucleic Acids Research·Ke-Wei ZhengZheng Tan
Oct 18, 2020·International Journal of Molecular Sciences·Andrés TittarelliFlavio Salazar-Onfray
Apr 25, 2021·Advanced Drug Delivery Reviews·Willemijn S de VoogtPieter Vader
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ohad SussDavid Margulies
Jul 7, 2021·Bioorganic & Medicinal Chemistry Letters·Ming-Sen ZhuJian-Feng Ge
Aug 19, 2017·Organic Letters·Qingyang ZhangHai-Yu Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.