PMID: 15374379Jul 1, 1992Paper

A molecular hybridization study for the presence of Herpes simplex, cytomegalovirus and Epstein-Barr virus in brain and blood of Alzheimer's disease patients

Archives of Gerontology and Geriatrics
S D KitturW H Adler

Abstract

Among several hypothesis for the development of Alzheimer's disease is a viral hypothesis. The present study was designed to detect nucleic acid sequences for conventional viruses in peripheral blood cells and brain of Alzheimer's disease patients. DNA was isolated from peripheral blood cells and brain tissue from control individuals and Alzheimer's disease patients. Southern blot analysis was performed using radiolabeled probes for various conventional viruses. The results fail to detect the presence of Herpes simplex 1 (HSV-I), Herpes simplex II (HSV-II), Epstein-Barr virus (EBV) and cytomegalo virus (CMV) at a sensitivity level of detecting 1 genome/100 cells. We exclude conventional viruses as a cause of Alzheimer's disease at this level of detection.

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Citations

Jan 26, 2013·Epidemiologic Reviews·Francis Mawanda, Robert Wallace
Dec 14, 2002·Annals of the New York Academy of Sciences·Marion BuckwalterTony Wyss-Coray
Dec 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ramcharan Singh AngomDebabrata Mukhopadhyay
Jun 30, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kie HonjoNicolaas P L G Verhoeff
Aug 5, 2016·Oncoscience·Federico Licastro, Elisa Porcellini
Jan 30, 2021·Microbial Cell Factories·Dana VigasovaJiri Damborsky

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