A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe

Chemistry : a European Journal
Qianni GuoXin Zhou

Abstract

Mercury pollution, in the form of mercury ions (Hg2+), is a major health and environmental hazard. Commonly used sensors are invasive and limited to point measurements. Fluorescence-based sensors do not provide depth resolution needed to image spatial distributions. Herein we report a novel sensor capable of yielding spatial distributions by MRI using hyperpolarized 129Xe. A molecular clamp probe was developed consisting of dipyrrolylquinoxaline (DPQ) derivatives and twocryptophane-A cages. The DPQ derivatives act as cation receptors whereas cryptophane-A acts as a suitable host molecule for xenon. When the DPQ moiety interacts with mercury ions, the molecular clamp closes on the ion. Due to overlap of the electron clouds of the two cryptophane-A cages, the shielding effect on the encapsulated Xe becomes important. This leads to an upfield change of the chemical shift of the encapsulated Xe. This sensor exhibits good selectivity and sensitivity toward the mercury ion. This mercury-activated hyperpolarized 129Xe-based chemosensor is a new concept method for monitoring Hg2+ ion distributions by MRI.

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Citations

Mar 2, 2017·Chemistry : a European Journal·Shengjun YangMaili Liu
Sep 13, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Michael T McMahon, Jeff W M Bulte
Aug 24, 2017·The Analyst·E Mari, P Berthault
Nov 7, 2018·Chemical Communications : Chem Comm·Bin ZhangXin Zhou
Oct 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Michael T McMahon, Assaf A Gilad
Apr 18, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaping YuanXin Zhou
Jun 28, 2017·Scientific Reports·Xianchun ZengChunqi Qian
May 22, 2018·Analytical Chemistry·Serge D ZemerovIvan J Dmochowski
Dec 29, 2020·Analytical Chemistry·Serge D ZemerovIvan J Dmochowski
Aug 28, 2020·Inorganic Chemistry·Kang DuIvan J Dmochowski
Aug 7, 2018·Chemical Reviews·Zhenchuang XuYanchuan Zhao

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