A molecular mechanism that confines the activity pattern of miR165 in Arabidopsis leaf primordia

The Plant Journal : for Cell and Molecular Biology
Kiyoshi TatematsuKiyotaka Okada

Abstract

In Arabidopsis leaf primordia, the expression of HD-Zip III, which promotes tissue differentiation on the adaxial side of the leaf primordia, is repressed by miRNA165/166 (miR165/166). Small RNAs, including miRNAs, can move from cell to cell. In this study, HD-Zip III expression was strikingly repressed by miR165/166 in the epidermis and parenchyma cells on the abaxial side of the leaf primordia compared with those on the adaxial side. We also found that the MIR165A locus, which was expressed in the abaxial epidermis, was sufficient to establish the rigid repression pattern of HD-Zip III expression in the leaf primordia. Ectopic expression analyses of MIR165A showed that the abaxial-biased miR165 activity in the leaf primordia was formed neither by a polarized distribution of factors affecting miR165 activity nor by a physical boundary inhibiting the cell-to-cell movement of miRNA between the adaxial and abaxial sides. We revealed that cis-acting factors, including the promoter, backbone, and mature miRNA sequence of MIR165A, are necessary for the abaxial-biased activity of miR165 in the leaf primordia. We also found that the abaxial-determining genes YABBYs are trans-acting factors that are necessary for the miR165 activity pa...Continue Reading

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Citations

Jul 17, 2015·Plant Signaling & Behavior·Kiyoshi TatematsuKiyotaka Okada
Apr 22, 2016·Plant Molecular Biology·Anna V ShchennikovaKonstantin G Skryabin
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Paz MereloMarcus G Heisler
Dec 14, 2018·Cellular and Molecular Life Sciences : CMLS·Naoyuki Uchida, Keiko U Torii
Jul 6, 2018·Frontiers in Plant Science·Thomas GrossAnnette Becker
Nov 9, 2018·Frontiers in Genetics·Michael André FritzAdrien Sicard
Dec 18, 2019·PeerJ·Eugeny TolstykoAndrey Solovyev
Jul 12, 2018·Development·Aude Maugarny-Calès, Patrick Laufs
Jan 21, 2021·International Journal of Molecular Sciences·Gaojie LiHongwei Hou

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