A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Fan QuHe-Feng Huang

Abstract

The objective of this study was to explore whether hyperandrogenism induces epigenetic alterations of peroxisome proliferator-activated receptor gamma 1 (PPARG1), nuclear corepressor 1 (NCOR1), and histone deacetylase 3 (HDAC3) genes in granulosa cells (GCs) of polycystic ovary syndrome (PCOS) women and whether these alterations are involved in the ovarian dysfunction induced by hyperandrogenism. Thirty-two infertile PCOS women and 147 infertile women with tubal blockage were recruited. PCOS women were divided into the hyperandrogenism (HA) PCOS group (n = 13) and nonhyperandrogenism (N-HA) PCOS group (n = 19). Sixty female Sprague-Dawley rats were used for PCOS model establishment. In GCs of HA PCOS women, PPARG1 mRNA expression was lower, whereas NCOR1 and HDAC3 mRNA expression were higher than N-HA PCOS women and controls (P < 0.05). When all women were divided into successful and failed pregnancy subgroups according to the following clinical pregnancy outcome, we found lower PPARG1 mRNA levels and higher NCOR1 and HDAC3 mRNA levels in the failed subgroup of HA PCOS (P < 0.05). Two hypermethylated CpG sites in the PPARG1 promoter and five hypomethylated CpG sites in the NCOR1 promoter were observed only in HA PCOS women (P <...Continue Reading

References

Jun 28, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N NikolettosK Diedrich
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·R AzzizUNKNOWN PCOS/Troglitazone Study Group
Aug 18, 2001·Molecular and Cellular Biology·M G GuentherM A Lazar
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Vicken Sepilian, Manubai Nagamani
Feb 8, 2005·Journal of the Society for Gynecologic Investigation·Vicken Sepilian, Manubai Nagamani
May 12, 2005·Médecine sciences : M/S·Pascal FromentPhilippe Monget
Dec 22, 2005·The Journal of Clinical Endocrinology and Metabolism·P PignyD Dewailly
Mar 9, 2006·The Journal of Clinical Endocrinology and Metabolism·Nectaria Xita, Agathocles Tsatsoulis
Jun 20, 2006·Steroids·Suhail A R DoiKamal A S Al-Shoumer
Jul 31, 2007·Reviews in Endocrine & Metabolic Disorders·Daniel A DumesicVasantha Padmanabhan
Aug 19, 2007·Oncogene·P Karagianni, J Wong
Aug 28, 2007·Lancet·Robert J NormanTheresa E Hickey
Jan 26, 2011·Nature Reviews. Endocrinology·Mark O GoodarziRicardo Azziz

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Citations

Apr 29, 2014·Reproductive Biomedicine Online·Izhar Ben-Shlomo, Johnny S Younis
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Fangfang WangHefeng Huang
Jul 31, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shuxia LiQihua Tan
Jan 9, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Aleksandra Rutkowska, Dominik Rachoń
Nov 28, 2014·Frontiers in Cell and Developmental Biology·Riya R KanherkarAntonei B Csoka
Nov 22, 2014·Human Reproduction Update·Ana B Crujeiras, Felipe F Casanueva
Jul 19, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shuxia LiQihua Tan
Mar 16, 2016·Scientific Reports·Milana KokosarElisabet Stener-Victorin
Sep 12, 2014·Revista da Associação Médica Brasileira·Leonardo Augusto LombardiEdmund Chada Baracat
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Pooja SagvekarSrabani Mukherjee
Dec 12, 2017·Journal of Cellular Physiology·Genmei JiaPengfei Xu
Apr 27, 2017·Reproduction, Fertility, and Development·Fatemeh EiniArash Bidadkosh
Aug 20, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Xuemei QiuShuqin Zhao
Jun 1, 2020·Human Reproduction·K W OlsenM L Grøndahl
Apr 15, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Bárbara EchiburúManuel Maliqueo
Jun 18, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Julia F LitzkyCarmen J Marsit
Apr 20, 2018·Genetics Research International·Roshan DadachanjiSrabani Mukherjee
Dec 10, 2019·Science China. Life Sciences·Lu WenZi-Jiang Chen
Jan 23, 2021·Problemy e̊ndokrinologii·K D IevlevaL V Suturina
Feb 5, 2021·Cell Metabolism·Nour El Houda MimouniPaolo Giacobini
Dec 29, 2020·Fertility and Sterility·Fangfang WangFan Qu
Apr 8, 2021·Reproductive Sciences·Matheus Credendio EirasCristiana Libardi Miranda Furtado
Mar 20, 2021·Biology of Reproduction·Leandro M VelezAlicia B Motta
Oct 4, 2019·Current Medicinal Chemistry·Alicia Beatriz Motta
Jul 9, 2021·Nature Reviews. Endocrinology·Elisabet Stener-Victorin, Qiaolin Deng
Apr 30, 2020·Saudi Journal of Biological Sciences·Salina Y Saddick

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