PMID: 8995688Feb 1, 1997Paper

A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3

Journal of Virology
V M HirschD Montefiori

Abstract

An infectious molecular clone of simian immunodeficiency virus SIVsm was derived from a biological isolate obtained late in disease from an immunodeficient rhesus macaque (E543) with SIV-induced encephalitis. The molecularly cloned virus, SIVsmE543-3, replicated well in macaque peripheral blood mononuclear cells and monocyte-derived macrophages and resisted neutralization by heterologous sera which broadly neutralized genetically diverse SIV variants in vitro. SIVsmE543-3 was infectious and induced AIDS when inoculated intravenously into pig-tailed macaques (Macaca nemestrina). Two of four infected macaques developed no measurable SIV-specific antibody and succumbed to a wasting syndrome and SIV-induced meningoencephalitis by 14 and 33 weeks postinfection. The other two macaques developed antibodies reactive in Western blot and virus neutralization assays. One macaque was sacrificed at 1 year postinoculation, and the survivor has evidence of immunodeficiency, characterized by persistently low CD4 lymphocyte subsets in the peripheral blood. Plasma samples from these latter animals neutralized SIVsmE543-3 but with much lower efficiency than neutralization of other related SIV strains, confirming the difficulty by which this molec...Continue Reading

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Citations

Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Silvija I StapransMark B Feinberg
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Apr 7, 2007·AIDS Research and Human Retroviruses·Takeo KuwataMasanori Hayami
Jan 21, 2011·AIDS Research and Human Retroviruses·Jaya Sastri, Edward M Campbell
Jul 26, 2014·Journal of Neurovirology·Lindsey Gerngross, Tracy Fischer
May 10, 2016·The Journal of Clinical Investigation·Kenta MatsudaVanessa M Hirsch
Sep 22, 2010·AIDS Research and Human Retroviruses·Takeo KuwataTatsuhiko Igarashi
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Nov 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jean D BoyerDavid B Weiner
Feb 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Timothy R FoutsRobert C Gallo
Sep 16, 2015·AIDS·Emi E Nakayama, Tatsuo Shioda
Aug 31, 2013·PLoS Pathogens·Fan WuVanessa M Hirsch
Nov 17, 2012·Nature Reviews. Microbiology·Theodora Hatziioannou, David T Evans

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