A molecularly imprinted polymer as the sorptive phase immobilized in a rotating disk extraction device for the determination of diclofenac and mefenamic acid in wastewater

Analytica Chimica Acta
Valentina ManzoPablo Richter

Abstract

The microextraction of diclofenac and mefenamic acid from water samples was performed by using rotating disk sorptive extraction (RDSE) with molecularly imprinted polymer (MIP) as the sorptive phase. The MIP was synthesized from the monomer 1-vinylimidazol (VI) together with the cross-linker divinylbenzene (DVB) using diphenylamine as the template molecule. Scanning electron microscopy (SEM) analyses of the MIP revealed clusters of spherical particles having a narrow size distribution, with diameters of approximately 1 μm. The optimized extraction conditions involved a disk rotation velocity of 3000 rpm, an extraction time of 120 min, a sample volume of 50 mL, and a sample pH of 2 as well as 25 mg of MIP immobilized in the disk. Desorption of the extracted analytes was performed with 5 mL of methanol for 10 min. Analysis by gas chromatography-mass spectrometry (GC-MS) was carried out after derivatization of the analytes with N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA). Nonmolecularly imprinted polymer (NIP) was also synthesized for comparison. It was observed that under the same conditions, MIP extracted significantly more NSAIDs containing diphenylamine (or part of this molecule) in their structure than NIP....Continue Reading

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Mar 19, 2014·Analytical and Bioanalytical Chemistry·Lourdes JacheroPablo Richter
May 13, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Carlos MuñozPablo Richter

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Citations

Nov 9, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mariana Roberto Gama, Carla Beatriz Grespan Bottoli
Jan 17, 2017·Analytical and Bioanalytical Chemistry·Carlos AlmeidaJosé Manuel F Nogueira
Nov 2, 2018·Environmental Science and Pollution Research International·Zama Emmaculate MbheleLawrence Mzukisi Madikizela

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