PMID: 6160098Jul 1, 1980Paper

A monoclonal antibody detecting the Ly-9.2 (Lgp 100) cell-membrane alloantigen

Immunogenetics
P M HogarthI F McKenzie

Abstract

A mouse monoclonal cell line (20-1.5) was produced by the cell fusion method and the antibody secreted by this line defined the Ly-9.2 specificity--the reciprocal specificity to that previously identified as the Lgp 100 or the T100 molecule. Although most concentrated on lymph-node cells, the antigen is also found on thymocytes, spleen and bone-marrow cells as well as liver and brain tissue. The monoclonal antibody precipitates a 100,000 molecular moiety from thymocytes. The antigenic specificities appear to be highly immunogeneic and antibodies to these specificities contaminate many antisera. These sera are noncytotoxic as is the case with the monoclonal antibody even though it is of the IgG2a subclass. As with T100 or Lgp 100, the Ly-9 locus appears to be linked to the H-25 locus.

References

Jan 1, 1979·Advances in Immunology·I F McKenzie, T Potter
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Mar 1, 1977·Somatic Cell Genetics·M L GefterM D Scharff
Jan 1, 1978·Journal of Immunological Methods·C R Parish, I F McKenzie
Dec 1, 1978·Immunogenetics·H I KohnD C Shreffler

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Citations

Jan 1, 1987·Immunogenetics·H C MorseU Hämmerling
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M F Seldin
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M F SeldinB Paigen
May 1, 1983·Human Immunology·R L Sparrow, I F McKenzie
Mar 13, 2001·Annual Review of Immunology·M MorraC Terhorst
Jan 12, 2011·Annual Review of Immunology·Jennifer L CannonsPamela L Schwartzberg
Dec 1, 1982·Journal of Immunogenetics·W Y LangdonG R Shellam
Feb 1, 1989·Immunological Reviews·H FestensteinG Biasi
Feb 1, 1981·Journal of Immunogenetics·T A PotterM C Cherry

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