PMID: 6166711May 1, 1981Paper

A monoclonal antibody that detects a V kappa-TEPC15 idiotypic determinant cross-reactive with a Thy-1 determinant

The Journal of Experimental Medicine
E Pillemer, I L Weissman

Abstract

To identify T lymphocyte antigens with immunoglobulin-like determinants, we prepared rat anti-mouse T cell monoclonal antibodies and screened them against a panel of purified mouse myeloma proteins representing all isotypes of immunoglobulin. One hybridoma, designated 42-21, was found to detect a novel antigenic determinant shared by V kappa-TEPC15 and the Thy-1 molecule on all T lymphocytes. Although several explanations for this unusual phenomenon exist, it may imply some role for the Thy-1 molecule in antigen and/or mitogen recognition. In any event, future studies of idiotypes on T lymphocytes must consider the possibility that anti-idiotypic sera detect cell surface molecules unrelated to classical immunoglobulin.

References

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Citations

Jan 1, 1982·Immunogenetics·M SuzanB Rubin
Jan 1, 1983·Pharmacology & Therapeutics·W E Magee, S S Ristow
Oct 1, 1988·Immunology Letters·S H FengA C Wang
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E A NiggS J Singer
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S S Katiyar, J W Porter
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E PillemerI L Weissman
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P P ChenD A Carson
Feb 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D LeiferS A Lipton
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·E B DreyerS A Lipton
Feb 1, 1982·The Journal of Experimental Medicine·A F Clark, J D Capra
May 1, 1984·The Journal of Experimental Medicine·R L RubinA N Theofilopoulos
Jun 1, 1990·The Journal of Experimental Medicine·A PuccettiR S Schwartz
Jul 1, 1986·Immunology Today·S Ghosh, A M Campbell
Jul 1, 1981·Immunology Today·C Morrison, B Coeshott
Feb 1, 1985·Journal of Neurochemistry·S HrubyN K Gonatas
Oct 1, 1984·Journal of Immunogenetics·O L OliveiraP Tippett
Oct 1, 1984·Immunological Reviews·D W LanckiF W Fitch
Apr 7, 1984·Journal of Theoretical Biology·V G Nesterenko
Dec 31, 1987·Biochemical and Biophysical Research Communications·Y KuwanaY Kurosawa
Sep 10, 1981·Nature·F Lepault, I L Weissman
Dec 16, 1982·Nature·J C Jensenius, A F Williams
Jul 7, 1983·Nature·A D Steinberg
Mar 18, 1982·Nature·D Lane, H Koprowski
May 14, 1982·Science·A F Williams, J Gagnon

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