PMID: 7546243Mar 1, 1995Paper

A monoclonal antibody to an early pregnancy factor-induced suppressor factor (EPF-S1) disrupts implantation in mice

American Journal of Reproductive Immunology : AJRI
S Athanasas-PlatsisH Morton

Abstract

The importance of EPF during pregnancy has been established previously but the importance of the EPF-induced suppressor factor EPF-S1 in pregnancy has to date been unaddressed. Investigations were therefore conducted in order to study this. Monoclonal antibodies to EPF-S1 were produced, and one antibody, designated R2T gamma, was characterized. Mated mice were passively immunized with R2T gamma and the effect on implantation determined. Characterization of anti-EPF-S1 R2T gamma revealed that it cross-reacted with EPF-S1 of different MHC restriction but not with EPF or EPF-S2. When injected into mated mice on days 1 to 4, R2T gamma had no effect on pregnancy but when injections continued to day 5, pregnancy was affected; the number of embryos implanted on day 7 were significantly less than the number of corpora lutea counted, signifying embryonic loss. These studies show that anti-EPF-S1 R2T gamma disrupts implantation in mice when injected on days 1 to 5 of pregnancy but not when injected on days 1 to 4, demonstrating that EPF-S1 exerts its effects around the time of implantation.

References

Jun 30, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·H MortonG J Clunie
Apr 12, 1979·Nature·F P NoonanG J Clunie
Nov 1, 1979·Journal of Reproduction and Fertility·C D NancarrowK E Turnbull
Jan 1, 1992·Reproduction, Fertility, and Development·H MortonB E Rolfe
May 1, 1991·Biology of Reproduction·B TartakovskyN Brosh
Jul 1, 1991·Journal of Reproduction and Fertility·S Athanasas-PlatsisP L Kaye
Jun 1, 1990·American Journal of Reproductive Immunology : AJRI·K D Beaman
Jan 1, 1990·Journal of Reproduction and Fertility·R C Hoversland, K D Beaman
Apr 1, 1990·Clinical and Experimental Immunology·K A QuinnH Morton
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B C Paria, S K Dey
Nov 1, 1989·Journal of Reproduction and Fertility·S Athanasas-PlatsisH Morton
Oct 1, 1988·Journal of Reproductive Immunology·S L RibbingK D Beaman
Jan 1, 1987·Current Topics in Developmental Biology·H MortonA C Cavanagh
Mar 1, 1988·Journal of Reproduction and Fertility·K D Beaman, R C Hoversland
Jun 1, 1995·American Journal of Reproductive Immunology : AJRI·B A RolfeA C Cavanagh
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K A QuinnH Morton

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Citations

Jun 1, 1995·American Journal of Reproductive Immunology : AJRI·B A RolfeA C Cavanagh
Dec 30, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·N TasdemirC Gulerman
Jan 20, 1999·Immunology and Cell Biology·H Morton

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