PMID: 6979606Jul 1, 1982Paper

A monoclonal T cell-replacing activity can act directly on B cells to enhance clonal expansion

The Journal of Experimental Medicine
G D WetzelR W Dutton

Abstract

We have used a B cell cloning system in which the response of a single isolated B cell to lipopolysaccharide and dextran sulfide can be followed. We have shown that culture supernatants from the Dennert long-term alloreactive T cell line C.C3.11.75 increase the frequency of B cells stimulated to clonal expansion by mitogens. These culture supernatants are devoid of interleukin 1 and 2 but contain the T cell-replacing factor activity (DL)TRF. These experiments provide unequivocal proof that a T cell-derived factor or factors can act directly on a B lymphocyte in the absence of any other cell.

References

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Mar 1, 1982·The Journal of Experimental Medicine·M HowardW E Paul

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Citations

Jun 10, 1986·Journal of Immunological Methods·H AbeJ J Oppenheim
May 1, 1983·The Journal of Experimental Medicine·M HowardW E Paul
Jan 1, 1983·Medical Microbiology and Immunology·M von Knebel DoeberitzH zur Hausen
Aug 28, 2004·Blood·Katia BassoRiccardo Dalla-Favera
Jan 1, 1985·European Journal of Immunology·R E CallardG W McCaughan
Jun 1, 1985·Scandinavian Journal of Immunology·E RuuthE Lundgren

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