A monocyte gene expression signature in the early clinical course of Parkinson's disease

Scientific Reports
Johannes C M SchlachetzkiJürgen Winkler

Abstract

Microglia are the main immune cells of the brain and express a large genetic pattern of genes linked to Parkinson's disease risk alleles. Monocytes like microglia are myeloid-lineage cells, raising the questions of the extent to which they share gene expression with microglia and whether they are already altered early in the clinical course of the disease. To decipher a monocytic gene expression signature in Parkinson's disease, we performed RNA-seq and applied the two-sample Kolmogorov-Smirnov test to identify differentially expressed genes between controls and patients with Parkinson's disease and changes in gene expression variability and dysregulation. The gene expression profiles of normal human monocytes and microglia showed a plethora of differentially expressed genes. Additionally, we identified a distinct gene expression pattern of monocytes isolated from Parkinson's disease patients at an early disease stage compared to controls using the Kolmogorov-Smirnov test. Differentially expressed genes included genes involved in immune activation such as HLA-DQB1, MYD88, REL, and TNF-α. Our data suggest that future studies of distinct leukocyte subsets are warranted to identify possible surrogate biomarkers and may lead to the...Continue Reading

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Citations

Aug 27, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Sara Konstantin NissenMarina Romero-Ramos
Apr 3, 2020·The Journal of Pharmacology and Experimental Therapeutics·Adithya GopinathWolfgang J Streit
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Nov 6, 2020·Experimental Biology and Medicine·Lille KurvitsAnu Planken
Dec 18, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Sara Konstantin NissenMarina Romero-Ramos
Feb 9, 2021·Acta Neuropathologica·Ashley S HarmsMarina Romero-Ramos
Mar 23, 2021·Frontiers in Immunology·Daniela C IvanGiuseppe Locatelli
Jul 3, 2021·Biomedicines·Ilenia SavinettiMaria Foti
Jun 29, 2021·Frontiers in Immunology·Austin P PassaroSteven L Stice
Jul 15, 2021·Journal of Neuroscience Research·Hermínio Maurício da Rocha SobrinhoFátima Ribeiro-Dias

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Datasets Mentioned

BETA
GSE89960

Methods Mentioned

BETA
density-gradient centrifugation
RNA-seq
flow cytometry
PCA

Software Mentioned

sklearn
scipy Python
HOMER
EdgeR
STAR
FlowJo
Forward Scatter

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