A mononuclear nonheme {FeNO}6 complex: synthesis and structural and spectroscopic characterization

Chemical Science
Seungwoo HongWonwoo Nam

Abstract

While the synthesis and characterization of {FeNO}7,8,9 complexes have been well documented in heme and nonheme iron models, {FeNO}6 complexes have been less clearly understood. Herein, we report the synthesis and structural and spectroscopic characterization of mononuclear nonheme {FeNO}6 and iron(iii)-nitrito complexes bearing a tetraamido macrocyclic ligand (TAML), such as [(TAML)FeIII(NO)]- and [(TAML)FeIII(NO2)]2-, respectively. First, direct addition of NO(g) to [FeIII(TAML)]- results in the formation of [(TAML)FeIII(NO)]-, which is sensitive to moisture and air. The spectroscopic data of [(TAML)FeIII(NO)]-, such as 1H nuclear magnetic resonance and X-ray absorption spectroscopies, combined with computational study suggest the neutral nature of nitric oxide with a diamagnetic Fe center (S = 0). We also provide alternative pathways for the generation of [(TAML)FeIII(NO)]-, such as the iron-nitrite reduction triggered by protonation in the presence of ferrocene, which acts as an electron donor, and the photochemical iron-nitrite reduction. To the best of our knowledge, the present study reports the first photochemical nitrite reduction in nonheme iron models.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Aug 29, 1998·Archives of Biochemistry and Biophysics·A SamouilovJ L Zweier
Sep 15, 1988·Physical Review A: General Physics·A D Becke
Jun 15, 1986·Physical Review. B, Condensed Matter·J P Perdew
Apr 11, 2002·Chemical Reviews·Peter C Ford, Ivan M Lorkovic
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hugues OuelletMichel Guertin
Jan 15, 2004·Journal of the American Chemical Society·József KaizerLawrence Que
Jan 13, 2006·Nature Chemical Biology·Mark T GladwinJon O Lundberg
Dec 23, 2006·Science·Filipe Tiago de OliveiraTerrence J Collins
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Oct 3, 2008·Chemical Research in Toxicology·Chang Hoon LimWilliam M Deen
Jan 28, 2009·Acta Crystallographica. Section D, Biological Crystallography·Anthony L Spek
Mar 18, 2009·Biochemical Society Transactions·Nicholas J WatmoughDavid J Richardson
Apr 30, 2009·Archives of Biochemistry and Biophysics·Jonathan L Cape, James K Hurst
Nov 1, 2011·Chemistry & Biology·Andrew G Tennyson, Stephen J Lippard
Nov 8, 2012·Chemical Communications : Chem Comm·Michael D Pluth, Stephen J Lippard
Feb 21, 2013·Journal of the American Chemical Society·Julie L HeineckePeter C Ford
Mar 25, 2014·Current Opinion in Chemical Biology·Ashley B McQuartersNicolai Lehnert
Jul 11, 2014·Journal of the American Chemical Society·Brian C SandersTodd C Harrop
Jun 10, 2015·Journal of Porphyrins and Phthalocyanines·Savita K SharmaKenneth D Karlin
Jun 27, 2015·Accounts of Chemical Research·Andrew P Hunt, Nicolai Lehnert
Aug 13, 2015·Nature Reviews. Drug Discovery·Jon O LundbergEddie Weitzberg
May 19, 2016·Journal of the American Chemical Society·Claudia KupperFranc Meyer
Nov 29, 2016·Antioxidants & Redox Signaling·Viktoria KuhnMiriam M Cortese-Krott
Dec 13, 2016·Journal of the American Chemical Society·Subrata KunduTimothy H Warren
Dec 23, 2016·Journal of the American Chemical Society·James J YanEdward I Solomon

❮ Previous
Next ❯

Citations

Sep 10, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohammed Ajmal Puthiyaveetil YoosafPankaj Kumar
Aug 15, 2018·Journal of the American Chemical Society·Amy L SpeelmanNicolai Lehnert
Nov 15, 2018·Journal of the American Chemical Society·Pui Man CheungJohn D Gilbertson

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
NMR

Software Mentioned

Bruker
EDG
SHELXTL
SAMPLE4
Orca
PySpline
SAINT
FIT
OPT
Gaussian

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.