A Monte Carlo algorithm for computing the IBD matrices using incomplete marker information

Heredity
Y Mao, S Xu

Abstract

Identity-By-Descent (IBD) is a general measurement of the relationship between two groups of genes. If the two groups consist of two homologous genes, one from each individual, the IBD is called the coancestry between the two individuals. Coancestry is an important concept in both population and quantitative genetics. It is the probability that both genes are copies of the same gene in the genealogy. The average coancestry value at a random locus in a population reflects the level of population diversity, effective population size, the level of inbreeding and other attributes. Coancestry is also the building block for the covariance structure used to estimate the additive genetic variance component for a quantitative trait. There are many other types of IBD matrices, depending on the natures of the genes included in each group, and these IBD matrices vary from locus to locus. Molecular markers distributed along the genome provide information that can be used to infer these locus-specific IBD matrices. As a result, we can estimate and test the variance components of a quantitative trait contributed by these loci using the inferred IBD matrices. In this study, we develop the concept of locus-specific epistatic IBD matrices and a ...Continue Reading

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Citations

Oct 31, 2008·Genome Research·Alexander GusevItsik Pe'er
Oct 27, 2007·BMC Bioinformatics·Dario GasbarraElja Arjas
Nov 21, 2013·Heredity·P Pikkuhookana, M J Sillanpää
Aug 2, 2007·American Journal of Human Genetics·Jianfeng LiuHong-Wen Deng
May 2, 2008·Journal of Applied Clinical Medical Physics·Juying ZhangMartin Fuss
Jun 20, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·William F SensakovicRebecca Vicenti

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