A Monte Carlo simulation of convective dispersion in the large airways

Respiration Physiology
S H Hobbs, E N Lightfoot

Abstract

A numerical model describing the local interactions between convection and diffusion in the first 11 generations (0 to 10) of the human bronchial tree is presented. The model, based on a Monte Carlo procedure, is used to investigate the effects of four velocity profiles: (i) parabolic, (ii) asymmetrical, (iii) asymmetrical with swirling and (iv) flat. Behavior was investigated for three diffusivities: (i) 0.75 cm2/s (He/air), (ii) 0.25 cm2/s (N2/O2) and (iii) 0.1 cm2/s (SF6/air) on the convection-diffusion interaction. The results of these simulations showed that 'Taylor dispersion' is an important effect, with respect to tracer segregation, and that it is of major significance only in the largest airways. By generation 10, molecular diffusion begins to dominate over Taylor dispersion. It was also found that use of a parabolic velocity profile, or application of the Gill-Sburamanian dispersion theory seriously overestimates axial dispersion. On the other hand, the use of a flat velocity profile underestimates dispersion.

References

Nov 1, 1976·Respiration Physiology·R W MazzoneL E Farhi
Mar 1, 1975·Respiration Physiology·C P Yu
Dec 1, 1974·Computers and Biomedical Research, an International Journal·M Paiva
Jan 1, 1973·Archives of Internal Medicine·D E OlsonG F Filley
Jul 1, 1973·Respiration Physiology·G R Stibitz
Sep 1, 1973·Respiration Physiology·H K Chang, L E Farhi
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Sep 1, 1973·Cardiovascular Research·R Brech, B J Bellhouse
Oct 1, 1969·Respiration Physiology·R C Schroter, M F Sudlow

Citations

Dec 1, 1981·Computers and Biomedical Research, an International Journal·A Ben JebriaJ F Boisvieux
Jan 1, 1984·International Journal of Bio-medical Computing·A Ben Jebria
Nov 1, 1984·International Journal of Bio-medical Computing·A Ben Jebria, P Varene

Related Concepts

Lobar Bronchus Structure
Mathematics
Monte Carlo Method
Respiration

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