Abstract
Traditional serrated adenoma (TSA) is the least common subtype of serrated colorectal polyp. Large protuberant lesions are easily recognised; however, the origins of TSAs are not known, and early forms have not been described. Some large TSAs present with a flat 'shoulder' component surrounding the central protuberant component. We hypothesised that small polyps with the same histology as these shoulder regions may represent early TSAs. Thus the primary aim of the study is to describe the histology of these presumptive early TSAs. We collected 70 small (<10 mm) polyps that may represent early TSAs on the basis of typical TSA cytology covering the luminal surface. We also identified 12 large TSAs with a shoulder component resembling these small polyps. The study polyp patients had a mean age of 58 years, and 54% were female; the polyps had a mean diameter of 4.1 mm and were predominantly distal (71%). Morphologically, slit-like serrations were present in 81%, ectopic crypt formations were present in 67%, and a villous component was present in 47%. These histological features were similar to those of the 12 shoulder lesions. Immunohistochemical stains showed an absence of β-catenin nuclear expression in 96% of the small polyps, r...Continue Reading
References
Jun 1, 1990·The American Journal of Surgical Pathology·T A Longacre, C M Fenoglio-Preiser
Apr 1, 1997·The American Journal of Surgical Pathology·M KangI Okayasu
Apr 19, 2007·Cancer Research·Daniel W RosenbergMichael J O'Brien
Mar 23, 2010·The American Journal of Surgical Pathology·Kyoung-Mee KimRobert D Odze
Jan 26, 2011·The American Journal of Surgical Pathology·Tatsuhiro IshiiVicki Whitehall
Jan 26, 2011·The American Journal of Surgical Pathology·Kohei FujitaYoshinao Oda
Aug 23, 2012·American Journal of Clinical Pathology·Baojin FuChristine A Iacobuzio-Donahue
Nov 15, 2013·American Journal of Clinical Pathology·Mi-Jung KimEui Gon Youk
Mar 8, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jia-Huei TsaiYung-Ming Jeng
Aug 16, 2014·The American Journal of Surgical Pathology·Homer O WilandRish K Pai
Sep 13, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mark L BettingtonVicki Lj Whitehall
Sep 30, 2014·Histopathology·Michael J O'BrienShi Yang
Jan 16, 2015·Journal of Clinical Pathology·Runjan ChettyLai Mun Wang
May 24, 2015·Human Pathology·Mark L Bettington, Runjan Chetty
Oct 18, 2015·Gut·Mark BettingtonVicki Whitehall
Mar 1, 2016·The Journal of Pathology·Shigeki SekineAtsushi Ochiai
Jul 29, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cheng LiuChristophe Rosty
May 24, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Taiki HashimotoShigeki Sekine
Citations
Mar 1, 2019·Histopathology·Antonio TravaglinoMaria D'Armiento
Dec 14, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Akiko ChinoSatoshi Nagayama
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rish K PaiChristophe Rosty
Jun 19, 2019·Virchows Archiv : an International Journal of Pathology·Yasuhiko MizuguchiShigeki Sekine
Jun 27, 2020·World Journal of Gastrointestinal Pathophysiology·Hongxing GuiRifat Mannan
Aug 16, 2019·BMJ Open Gastroenterology·Aoife J McCarthyRunjan Chetty
Dec 7, 2020·Gastroenterology·William M GradySanford D Markowitz