PMID: 6991507Feb 1, 1980Paper

A morphological study of plasma and phagosome membranes during endocytosis in Acanthamoeba

The Journal of Cell Biology
B Bowers

Abstract

Particle ingestion by Acanthamoeba is rapid. Within 40 s bound particles can be surrounded by pseudopods, brought into the cytoplasm, and released as phagosomes into the cytoplasmic stream. In electron micrographs the phagosome appears as a flasklike invagination of the surface. Separation from the surface occurs by fragmentation of the attenuated "neck+ of the invagination. The separated phagosome membrane has a three- to fourfold greater density of intramembrane particles than the plasma membrane from which it derives. This change is evident within 15 min of ingestion and is detectable while the membrane is still tightly apposed to the particle. There is no direct evidence for the mechanism of this increase; no increase in particle density was seen in the membrane at an early stage in the forming phagosomes still connected to the surface. These morphological observations are consistent with chemical analyses, to be reported in a separate communication, that show that the phagosome membrane has a higher protein to phospholipid ratio and a higher glycosphingolipid content than the plasma membrane. Enlarged phagosomes (presumptive phagolysosomes) show multiple small vesiculations of characteristic morphology. The small vesicles ...Continue Reading

References

Nov 1, 1977·The Journal of Cell Biology·Y Kitajima, G A Thompson
May 10, 1979·Nature·A J VerkleijP H Ververgaert
Dec 1, 1977·Experimental Cell Research·B Bowers
Mar 1, 1976·The Journal of Cell Biology·R M SteinmanZ A Cohn
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Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

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Citations

Jan 1, 1985·Comparative Immunology, Microbiology and Infectious Diseases·A Ryter
Apr 1, 1981·The Journal of Cell Biology·R D Allen, L A Staehelin
Jan 1, 1983·The Journal of Cell Biology·R M SteinmanZ A Cohn
Aug 1, 1983·The Journal of Cell Biology·B Bowers, T E Olszewski
Aug 1, 1983·The Journal of Cell Biology·R D Allen, A K Fok
Aug 1, 1985·The Journal of Experimental Medicine·G B BaileyJ W Gasque
Sep 1, 1993·The Journal of Eukaryotic Microbiology·T C Hohman, B Bowers
Feb 1, 1982·The Anatomical Record·B F King
Nov 26, 2013·Parasitology International·Edwin MurungiAlan Christoffels
Sep 9, 1985·Biochimica Et Biophysica Acta·L Thilo
Apr 1, 1981·Molecular and Cellular Biology·C F Bailey, B Bowers
Feb 1, 1982·Experimental Parasitology·K YonedaM G Birk

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