A morphometric analysis of the hypertrophy of experimental liver cirrhosis

Virchows Archiv. A, Pathological Anatomy and Histopathology
J W Ryoo, R J Buschmann

Abstract

The objective of this study was to better elucidate the composition of the hypertrophic cirrhotic liver. We induced cirrhosis with hypertrophy in rats by simultaneous treatment with CCl4 and phenobarbital (PB) and devised a hierarchy of structure applicable to the sampling and morphometric analysis of untreated and PB-treated control livers and of cirrhotic livers. Our analysis demonstrated that the hepatomegaly attributable to cirrhosis is virtually the total result of an increase in the specific volume (ml/100 g body weight) of the non-parenchyma, most of which is connective tissue and vascular lumen volume. Inconsequential to the hepatomegaly but statistically significant were the volumetric increases found in the following parenchymal compartments: hepatocyte nucleus, Kupffer/endothelial cell nucleus, Ito cell nucleus and cytoplasm, and bile canaliculus. The change in the hepatocyte nucleus is the result of an increase in size rather than in number. Sinusoidal space is the only compartment that showed a significant decrease. This study shows the practicality and usefulness of applying morphometric methods to cirrhotic liver.

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Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·C Pesce, R Colacino
Nov 1, 1994·Journal of Gastroenterology and Hepatology·Y MatsuiY Kamiyama
Jul 1, 1989·Journal of Clinical Pathology·J W Ryoo, R J Buschmann
Nov 1, 1985·The Journal of Clinical Investigation·F Varin, P M Huet
Sep 1, 1991·Digestive Diseases and Sciences·F CalleaM Favret
May 1, 1989·Pathology, Research and Practice·C M Pesce, F S Carli
Jun 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·O Löw
Feb 1, 1989·Experimental and Molecular Pathology·R J Buschmann, J W Ryoo
Aug 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·V PlourdeP M Huet
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H ImamuraY Idezuki
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E GaudioO Riggio
May 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J B GrossA Zimmermann

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