PMID: 7541265Apr 1, 1995Paper

A morphometric and statistical study of the effects of soft laser (He-Ne) irradiation on the pineal gland

Histology and Histopathology
M D Guillot VallsF Martinez-Soriano

Abstract

Thirty-six male Wistar rats (225g average b.w.) were studied after direct He-Ne laser irradiation (632.8 nm, 5 mW) of the surgically-exposed pineal gland. Total irradiation time was 5 minutes, with rest intervals of 1 minute for every minute of irradiation. The animals were sacrificed in groups of 4 (controls, irradiated animals and sham-operated rats--i.e., craniotomy without irradiation) on days 3, 7 and 10 postirradiation. A significant increase was seen (p < 0.0001) in the medullary and cortical karyometric indices of the pineal body in all experimental, control and sham-operated animals. The increase was greatest (over 50%) on day 3 postirradiation among the experimental animals, with respect to the control and sham-operated groups. A progressive and significant decrease in karyometric index (p < 0.05) was in turn observed on days 7 and 10 postirradiation, although the values remained higher than among the controls. Ultrastructurally, there were cytoplasmic signs of an increase in metabolic activity in the experimental animals on days 3 and 7, followed by a decrease in activity by day 10 with the appearance of numerous lipid droplets, pericanallicular dark cells and mesoglial cells. We suggest that laser irradiation stimul...Continue Reading

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