PMID: 6539397May 1, 1984Paper

A morphometrical study of myocardial disarray associated with right ventricular outflow tract obstruction

Japanese Circulation Journal
S KawaiS Saito

Abstract

In order to define quantitatively the histological characteristics of the hypertrophied myocardium of the right ventricular outflow tract in patients with congenital heart disease, a light-microscopic study of biopsy specimens obtained from 20 cases with tetralogy of Fallot (TOF) and 14 cases with muscular obstruction of the right ventricular outflow tract ( RVOTO ) was performed using a semi-automatic sampling counter. As the controls, the crista supraventricularis of 11 autopsied cases without cardiac disease were used. The TOF patients were divided into two groups: those with (9 cases) or without (11) a history of hypoxic spells. The myocyte diameter was calculated according to Chalkley 's and Arai 's method. The areas of myocardial fibrosis and myocyte disarray were determined quantitatively by the point count method. Myocardial fibrosis was classified into five types: focal, mild perimysial, severe perimysial, perivascular and plexiform. In the control group, the myocyte diameter and area of fibrosis and disarray tended to increase with age. In the obstructive groups, the myocyte diameter and area of disarray were greater than those of the control in any age group. Myocyte diameter tended to increase with age in all groups...Continue Reading

Citations

Jan 6, 2006·The Journal of Clinical Investigation·Brian L StaufferLeslie A Leinwand
May 12, 2011·Current Cardiology Reports·Ronn E Tanel
Mar 5, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Nicola PradeganRobert F Padera
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Sep 15, 1993·The American Journal of Cardiology·M MitsunoY Kawashima
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