A Mother-to-Child Transmission Study in Nigeria: The Impact of Maternal HIV Infection and HAART on Plasma Immunoglobulins, Cytokine Profiles and Infant Outcome.

Virologica Sinica
Chinwe O Ewenighi-AmankwahLijun Rong

Abstract

Prevention of mother-to-child transmission (PMTCT) of HIV with highly active antiretroviral therapy (HARRT) allows the HIV+ pregnant mothers to have vaginal delivery and breastfeed. Here we investigated the maternal plasma immunoglobulin, cytokine secretion and the outcome of the exposed infants among the HIV+ HAART treated pregnant women in Nigeria. In this study, different plasma immunoglobulins and cytokines were measured in the HIV+ HAART treated pregnant mothers. Pooled culture supernatants of B and T lymphocytes showed lower levels of IFN-γ, IL-10 and IL-4. There were lower IFN-γ and IL-10 secretions at 1st trimester; however, IL-10 continued to be lower throughout 2nd and 3rd trimesters. TNF-α secretion significantly decreased as pregnancy progressed to term. There were high plasma IgG and low IgM in the HIV+ HAART treated pregnant women. Plasma IgG was high during 1st and 3rd trimesters. After one year of follow up, all the exposed children were seronegative for HIV-1 and HIV-2. Vaginal delivery and breastfeeding among HIV+ HAART treated mothers have shown to be safe. The use of HAART by the infected mothers and the use of septrin and niverapin by the exposed infants prevented mother to-child transmission of HIV.

References

May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·William R BurnsGeorge Tellides
Jan 21, 2006·Journal of Reproductive Immunology·Simona FioreMario Clerici
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Sep 23, 2006·The Journal of Infectious Diseases·Susan E PachecoUNKNOWN Women and Infants Transmission Study
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Jan 15, 2013·American Journal of Obstetrics and Gynecology·Steffen KunzmannBoris W Kramer

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Citations

Jul 9, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·H M SebitloaneJ Moodley

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Methods Mentioned

BETA
cesarean section
density gradient centrifugation
enzyme-linked immunosorbent assay
ELISA
PCR

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