PMID: 1212099Jan 1, 1975Paper

A mouse hepatotropic variant of influenza virus

Archives of Virology
O Haller

Abstract

A hepatotropic variant of avian influenza virus A/Turkey/England 63 (Hav 1, Nav 3) was selected by serial passages in mouse liver. Adaptation to this organ was established after 13 in vivo passages and was found to improve during further passages as shown by increasing rates of replication in livers of ICR mice. The mutant virus finally selected was stable and differed from the original virus mainly in lethality upon intraperitoneal injection in mice, in its ability to grow to high titers in livers of susceptible animals and in plaque morphology in chick embryo fibroblasts. No differences were detected in hemagglutination inhibition and neutralization by standard mouse antisera. Pathogenicity for the liver was independent of the route of inoculation, included other laboratory animals sensitive to influenza virus and could be inhibited by amantadine. Fatal hepatitis in 50 per cent of susceptible mice by the intraperitoneal route required from 10 to 20 EID50-. Pathological changes consisted of severe necrosis of liver parenchyma accompanied by release of F antigen into the serum and were apparently due to virus replication in hepatic cells as evidenced by immunofluorescence. The main implications of this animal model for studies ...Continue Reading

References

Jan 1, 1975·Archives of Virology·O HallerJ Lindenmann
Jan 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C SauterJ Lindenmann
Jul 1, 1967·The Journal of Experimental Medicine·J Lindenmann, P A Klein
May 1, 1968·The Journal of General Virology·C K Paniker
Dec 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·J W McGahen, C E Hoffmann
Jan 1, 1965·Archiv für die gesamte Virusforschung·J S Oxford, G C Schild
Dec 1, 1957·The Australian Journal of Experimental Biology and Medical Science·C A MIMS
Mar 1, 1964·Bacteriological Reviews·C A MIMS
May 15, 1964·Science·W L DAVIESC E HOFFMANN
Sep 1, 1948·The Journal of Experimental Medicine·W F FRIEDEWALD, E W HOOK

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Citations

Jan 1, 1983·Archives of Virology·J Bonin, C Scholtissek
Mar 1, 1979·The Journal of Experimental Medicine·O HallerJ Lindenmann
Feb 6, 2014·PloS One·Pascale HermantThomas Michiels
Nov 1, 1993·Immunobiology·T PeschkeD Gemsa
Oct 10, 1998·Journal of Virology·A García-SastreJ E Durbin

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