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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

PLoS Genetics

Aug 15, 2009

Chris ChurchRoger D Cox

Abstract

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstr...read more

Mentioned in this Paper

Vertebrates
C3H/HeH Mouse
Metabolic Process, Cellular
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Brown Fat
Biochemical Pathway
Microarray Analysis
Glucagon (rDNA)
Urine
1
169
Paper Details
References
  • References40
  • Citations151
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  • References40
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Related Papers

Nature Genetics

Overexpression of Fto leads to increased food intake and results in obesity

Nature GeneticsNovember 16, 2010
Chris ChurchRoger D Cox
International Journal of Obesity : Journal of the International Association for the Study of Obesity

The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents

International Journal of Obesity : Journal of the International Association for the Study of ObesityOctober 12, 2011
D M HallmanG S Berenson
© 2020 Meta ULC. All rights reserved

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

PLoS Genetics

Aug 15, 2009

Chris ChurchRoger D Cox

PMID: 19680540

DOI: 10.1371/journal.pgen.1000599

Abstract

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstr...read more

Mentioned in this Paper

Vertebrates
C3H/HeH Mouse
Metabolic Process, Cellular
Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
Brown Fat
Biochemical Pathway
Microarray Analysis
Glucagon (rDNA)
Urine
1
169

Feeds With Similar Papers

Inflammation & Obesity

Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state. Discover the latest research on inflammation and obesity here.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Nature Genetics

Overexpression of Fto leads to increased food intake and results in obesity

Nature GeneticsNovember 16, 2010
Chris ChurchRoger D Cox
International Journal of Obesity : Journal of the International Association for the Study of Obesity

The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents

International Journal of Obesity : Journal of the International Association for the Study of ObesityOctober 12, 2011
D M HallmanG S Berenson
Paper Details
References
  • References40
  • Citations151
1234
  • References40
  • Citations151
12345...

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