PMID: 6163950Jan 1, 1980Paper

A mouse model of the pathogenesis and postexposure prophylaxis of rabies

Microbiology and Immunology
K MifuneK Sakamoto

Abstract

A mouse model for the study of postexposure prophylaxis of rabies was established. Mice injected intramuscularly with a street strain of rabies virus were significantly protected from death by five daily 0.2-ml doses of inactivated rabies vaccine of chick embryo cell culture origin initiated immediately or 3 hr after infection. In these mice, a large amount of circulating interferon was induced as early as 1 hr after the first dose of vaccine and lasted until at least 12 hr but no such amount of interferon was induced by additional doses of vaccine. Serum antibody was first detected in the mice on day 6. It was noted that some of the surviving mice manifested an ataxia or paralysis of the legs. Increasing mortality rates were shown in mice treated with decreasing doses of the vaccine. Passive protection tests using concentrated IgG and IgM antibodies with equivalent neutralization titers showed that IgG antibody gave total protection when given 24 hr before the infection, while it was almost totally ineffective in reducing the mortality when given 2 days or more after infection. IgM antibody did not protect the mice even when given 24 hr before infection. These results suggest that interferon production is more important than a...Continue Reading

References

Jan 1, 1977·Intervirology·A L SmithT Motohashi
Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T J WiktorH Koprowski
Sep 1, 1978·The Journal of General Virology·G S Turner
Jan 1, 1977·Archives of Virology·F A Murphy
Apr 1, 1972·The Journal of Infectious Diseases·B Janis, K Habel
May 1, 1972·The Journal of Infectious Diseases·G M Baer, W F Cleary
Oct 1, 1972·The Journal of Infectious Diseases·T J WiktorH Koprowski
Jan 1, 1974·Advances in Immunology·H L Spiegelberg

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Citations

Sep 1, 1991·Vaccine·R Jayakumar, P Ramadass
Jan 1, 1992·Microbiology and Immunology·K HiraiK Mannen
Dec 15, 2015·The Journal of Infectious Diseases·Kentaro YamadaAkira Nishizono
Jan 1, 1981·Microbiology and Immunology·K MifuneK Sakamoto

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