A Mouse Model of Transplacental Cocaine Exposure: Clinical Implications for Exposed Infants and Children(a)

Annals of the New York Academy of Sciences
Barry E Kosofsky, Aaron S Wilkins

Abstract

To characterize the effects of cocaine on developing brain we have developed a mouse model of gestational cocaine exposure. We studied pregnant dams injected twice daily with cocaine HCl at 40, 20, or 10 mg/kg/day sc from embryonic days (E)8 to E17 (COC 40, COC20, and COC10, respectively), vehicle-injected dams allowed access to food ad libitum (SAL) or pair-fed with the COC 40 dams (SPF 40), animals pretreated with the short-acting α-adrenergic antagonist phentolamine prior to each cocaine injection (P COC 40), and animals administered phentolamine prior to saline (PHENT). COC 40, P COC 40, and SPF 40 dams demonstrated the lowest percentage weight gain during gestation. The surrogate-fostered offspring of COC 40, P COC 40, and SPF 40 dams demonstrated transient brain and body growth retardation on postnatal days (P)1 and P9 when compared to pups born to SAL dams. We conducted behavioral tests which allowed us to dissociate the indirect effect of cocaine-induced malnutrition from a direct effect of prenatal cocaine administration in altering postnatal behavior. Pups from all groups were tested for first-order Pavlovian conditioning on P9 or P12 or for the ability to ignore redundant information in a blocking paradigm on P50. Un...Continue Reading

References

Jun 8, 1992·Neuroscience Letters·P GressensP Evrard
Sep 1, 1992·Neurotoxicology and Teratology·P J Bilitzke, M W Church
Nov 1, 1992·Neurotoxicology and Teratology·G A GoodwinL P Spear
Jan 1, 1992·Neurotoxicology and Teratology·C J HeyserL P Spear
Aug 6, 1992·The New England Journal of Medicine·J J Volpe
Dec 1, 1991·Pediatric Clinics of North America·B Zuckerman, K Bresnahan
Mar 1, 1990·Pharmacology, Biochemistry, and Behavior·S K SobrianL M Turner
Jan 1, 1990·Annual Review of Neuroscience·M I Posner, S E Petersen
Oct 1, 1990·Brain Research. Developmental Brain Research·D J BurchfieldK J Gerhardt
Jan 1, 1989·Neurotoxicology and Teratology·R F SmithS L Kurtz
Jan 1, 1989·Neurotoxicology and Teratology·L P SpearN E Spear
Jan 1, 1989·Neurotoxicology and Teratology·D E HutchingsD L Dow-Edwards
Feb 20, 1987·JAMA : the Journal of the American Medical Association·J R WoodsK E Clark
Jan 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·N M Gonzalez, M Campbell
Jul 1, 1994·Journal of Child Neurology·R J KonkolG D Olsen
Sep 1, 1993·Neurotoxicology and Teratology·P M KunkoS E Robinson
Dec 1, 1995·Journal of Speech and Hearing Research·M Mentis, K Lundgren
Oct 1, 1996·The Journal of Pediatrics·S W JacobsonL M Chiodo

❮ Previous
Next ❯

Citations

Sep 15, 2005·Memory & Cognition·Michael F VerdeBrian H Ross
Aug 31, 2006·Behavioural Pharmacology·Josefina EstellesJosé Miñarro
Jun 15, 2007·Journal of Developmental and Behavioral Pediatrics : JDBP·Veronica H AccorneroEmmalee S Bandstra
Apr 2, 2005·Journal of Pediatric Psychology·Teresa J LinaresSonia Minnes
Jun 28, 2016·Birth Defects Research. Part C, Embryo Today : Reviews·Melissa M MartinGregg D Stanwood
Sep 2, 2000·Pediatrics·D A Bateman, C A Chiriboga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.