PMID: 58948Apr 1, 1976

A mouse plasma substance carrying beta2-microglobulin activity and lacking in H-2 alloantigenic activity

Journal of Immunogenetics
T NatoriD Pressman

Abstract

A mouse plasma substance carrying beta-2-microglobulin activity and lacking in H-2 alloantigenic activity was separated from the blood plasma of A/J strain female mice. The plasma substance had a molecular size of about 300,000-400,000 daltons and an electrophoretic mobility of alpha-globulin. The plasma substance was split by papain digestion to a fragment of about 50,000-60,000 daltons that still carried beta2-microglobulin activity. The papain-split plasma substance was devoid of H-2 alloantigenic activities and Thy-1 and TL alloantigenic activities as well, but yet had a two-component structure that was similar to papain-solubilized H-2 molecules. It contained a 37,000-dalton component linked non-covalently to an 11,00-dalton component, i.e. mouse beta2-microglobulin. This plasma substance appears to be different from Ss protein or Slp protein, both found in mouse serum.

References

Feb 27, 1975·Nature·L OstbergP A Peterson
Sep 1, 1975·The Journal of Experimental Medicine·J D CapraJ Klein
Jan 1, 1975·The Journal of Experimental Medicine·F D FindelmanW E Paul
Jul 22, 1975·Biochemical and Biophysical Research Communications·T NatoriD Pressman
Jan 1, 1975·International Urology and Nephrology·E Proca, D Nicolescu
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
Jan 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonJ B Lindblom
Dec 1, 1974·Transplantation·T NatoriD Pressman
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·D SwanP Leder
Oct 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·O Smithies, M D Poulik
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·K NakamuroD Pressman
Apr 23, 1974·Biochemical and Biophysical Research Communications·I Berggård
Jun 28, 1974·Nature·L RaskP A Peterson
Sep 7, 1967·Biochemical and Biophysical Research Communications·A L ShapiroJ V Maizel
Dec 28, 1964·Annals of the New York Academy of Sciences·B J DAVIS

Citations

Jun 1, 1981·Molecular Immunology·L Björck, I Berggård
Aug 1, 1983·Molecular Immunology·L Lögdberg, L Björck
Oct 1, 1987·Human Immunology·M S Krangel
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J R ParnesJ G Seidman
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W L MaloyG Jay
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L BjörckW Kastern
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y BushkinE A Boyse
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M J SoloskiA Lattimore
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P J Robinson
Jul 1, 1984·The Journal of Experimental Medicine·J FujimotoR Levy
Jan 1, 1981·Scandinavian Journal of Immunology·L LögdbergL Björck

Related Concepts

Beta(1)CA Globulin
Beta-2 Microglobulin
Serum Proteins
SD Antigens
HLA Antigens
Mice, Inbred A
Protein Conformation

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