A moveable 5' splice site in adenine phosphoribosyltransferase genes of Drosophila species.

Molecular and Cellular Biology
D H Johnson, S Henikoff

Abstract

In two distantly related Drosophila species, the use of alternate 5' splice sites to process an intron in pre-mRNA from homologous adenine phosphoribosyltransferase (APRT)-encoding genes led to RNAs encoding nonfunctional peptides in addition to APRT. The production of aberrantly spliced transcripts as a normal feature of gene expression supports a general model of eucaryotic gene evolution through alternative splicing and moveable splice junctions.

References

Feb 9, 1978·Nature·W Gilbert
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T A Kunkel
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jun 10, 1983·Science·C S CraikR Fletterick
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·D H Johnson, T B Friedman
Jan 22, 1982·Nucleic Acids Research·S M Mount

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