PMID: 6971877May 1, 1981Paper

A mucosal antibody response following systemic Haemophilus influenzae type B infection in children

The Journal of Clinical Investigation
M E PichicheroR A Insel

Abstract

The possibility that mucosal antibody is produced as a host response to Haemophilus influenzae type b (Hib) infection was examined in this study. 17 of 18 prospectively evaluated children ranging in age from 2 mo to 7 yr developed a detectable level of anticapsular antibody in their nasopharyngeal secretions after systemic Hib infection. The mean concentration of nasal anti-capsular antibody of the 18 children was 554 ng/mg IgA (SD = 35-8,863) during the acute phase of illness and declined to 224 ng/mg IgA (SD = 19-2,688) in convalescence. Some children had mucosal antibody detectable at least 10 mo after infection. The mucosal antibody levels were not affected by the length of illness before diagnosis, type of disease, age of the patient, sex, or presence of detectable capsular antigen or viable bacteria in the nasopharynx. The mucosal antibody was predominantly of the IgA class and occurred independent of the serum antibody. Six of the children aged less than 1 yr who did not produce and/or sustain a serum antibody level correlated with protection demonstrated a persistent mucosal antibody response. These findings suggest that the mucosal immune system may have the ability to respond at an earlier age than the serum immune sy...Continue Reading

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Nov 1, 1980·The Journal of Infectious Diseases·M E PichicheroR A Insel

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Citations

Nov 1, 1995·Clinical and Diagnostic Laboratory Immunology·A VirolainenM Leinonen
May 9, 2002·International Journal of Pediatric Otorhinolaryngology·Yuji Yokoyama, Yasuaki Harabuchi
Jun 3, 2005·The Pediatric Infectious Disease Journal·Michael E Pichichero, Janet R Casey
Aug 3, 2012·Clinical and Vaccine Immunology : CVI·Ravinder KaurMichael E Pichichero
Sep 29, 2004·Journal of Clinical Pathology·Q Zhang, A Finn
Jun 28, 2005·Drugs·Janet R Casey, Michael E Pichichero
Mar 13, 2012·Influenza and Other Respiratory Viruses·Yong HeJennifer L Reed
Aug 21, 2013·Human Vaccines & Immunotherapeutics·Michael E Pichichero
Nov 1, 1983·The Journal of Allergy and Clinical Immunology·M E Pichichero, R A Insel
Jan 23, 2009·FEMS Immunology and Medical Microbiology·Mirja Puolakkainen
May 1, 1995·Infection and Immunity·C BergquistJ Holmgren

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