Abstract
Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae (KPC-CRE) are multidrug-resistant organisms causing morbidity and mortality worldwide. KPC-CRE prevalence is increasing in pediatric populations, though multi-centered data are lacking. Identifying risk factors for KPC-CRE infection in children and classifying genotypes is a priority in this vulnerable population. A case-case-control study of patients (0-22 years) at 3 tertiary-care Chicago-area medical centers, 2008-2015, was conducted. Case group 1 children possessed KPC-CRE infections; case group 2 harbored carbapenem-susceptible Enterobacteriaceae (CSE) infections; controls had negative cultures. Case-control matching was 1:1:3 by age, infection site and hospital. Statistical and molecular analyses were performed. Eighteen KPC-CRE infections were identified; median patient age was 16.5 years. Of 4 available KPC-CRE, 2 were unrelated, non-ST258 KP strains harboring blaKPC-2, one was a ST258 KP harboring blaKPC-3, and the last was an E. coli containing blaKPC-2. KPC-CRE and CSE-infected patients had more multidrug-resistant organisms infections, long-term care facility admissions and lengths of stay (LOS) > 7 days before culture. KPC-CRE and CSE patients h...Continue Reading
References
May 4, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Keith S KayeYehuda Carmeli
Oct 29, 2009·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Leanne B GasinkNeil O Fishman
Feb 24, 2010·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L Silvia Munoz-PriceRobert A Weinstein
Jul 12, 2011·Annual Review of Microbiology·Karen Bush, Jed F Fisher
Nov 8, 2011·International Journal of Antimicrobial Agents·Malaika L LittleScott J Weissman
Nov 26, 2011·Journal of Clinical Microbiology·Delphine GirlichPatrice Nordmann
Apr 12, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roberto A ViauRobert A Bonomo
Jun 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Latania K Logan
Aug 16, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael Y LinUNKNOWN Centers for Disease Control and Prevention Epicenters Program
Aug 24, 2013·The Lancet Infectious Diseases·L Silvia Munoz-PriceJohn P Quinn
Feb 26, 2014·Journal of the Pediatric Infectious Diseases Society·Jasmeen S DaraRebecca Pellett Madan
Mar 8, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sahera Dirajlal-FargoXiaoyan Song
Jun 11, 2014·Antimicrobial Agents and Chemotherapy·Meredith S WrightMark D Adams
Jun 26, 2014·MBio·Liang ChenBarry N Kreiswirth
Aug 6, 2014·The Pediatric Infectious Disease Journal·Pia S PannarajScott J Weissman
Oct 22, 2015·Emerging Infectious Diseases·Latania K LoganUNKNOWN Prevention Epicenters Program
Nov 20, 2015·Journal of the Pediatric Infectious Diseases Society·Terri StillwellAndrew Nowalk
Dec 2, 2015·Journal of the Pediatric Infectious Diseases Society·Latania K LoganUNKNOWN CDC Epicenters Prevention Program
Feb 19, 2016·Journal of Clinical Microbiology·Scott A CunninghamRobin Patel
Mar 30, 2016·Antimicrobial Agents and Chemotherapy·Latania K LoganRobert A Bonomo
Jul 16, 2016·Open Forum Infectious Diseases·Latania K Logan, Robert A Bonomo
Apr 5, 2017·The Journal of Infectious Diseases·Latania K Logan, Robert A Weinstein
May 16, 2017·Diagnostic Microbiology and Infectious Disease·Eleanor A PowellJoel E Mortensen
Oct 4, 2017·Antimicrobial Agents and Chemotherapy·Kathleen ChiotosJennifer H Han
Citations
Dec 18, 2019·Antimicrobial Agents and Chemotherapy·David Aguilera-AlonsoFernando Baquero-Artigao
Feb 6, 2020·Antimicrobial Agents and Chemotherapy·Latania K LoganAmy Pruden
Jul 19, 2019·Journal of Pediatric Hematology/oncology·Michal Vinker-ShusterDiana Averbuch
Sep 3, 2021·The Pediatric Infectious Disease Journal·Silvia GarazzinoElio Castagnola