A Multi-crosslinking Nanocapsule-Based Serial-Stimuli-Responsive Leakage-Free Drug-Delivery System In Vitro

Chemistry : a European Journal
Yazhou LiuXiaoling Zhang

Abstract

As some stimuli utilized in conventional drug delivery systems can also be found in normal cells, it is inevitable that encapsulated drugs escape from carriers into normal cells. Based on mutual interactions among proteins, polyphenol compounds, and metal ions, we developed a serial-stimuli-responsive drug delivery system. With multi-crosslinking structure, nanocapsules can maintain the integrity of the framework, even with a certain amount of stimuli present, and eventually reach tumor cells to initiate apoptosis, and protect normal cells from being damaged. Meanwhile, the fluorescence of DOX will be quenched when encapsulated in nanocapsules. This property means that the DOX that is released from nanocapsules can be monitored in real-time based on the recovery of fluorescence. These versatile nanocapsules exhibit great potentials to treat cancer.

References

Aug 11, 2006·Nature Reviews. Cancer·Ruth Duncan
Sep 15, 2010·Molecular Pharmaceutics·Weiwei GaoOmid C Farokhzad
Jun 5, 2012·Nature Nanotechnology·Jun GeRichard N Zare
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Apr 15, 2014·ACS Nano·James D RobertsonGiuseppe Battaglia
Oct 8, 2014·Nature Reviews. Drug Discovery·Vladimir P Torchilin
May 20, 2015·ACS Applied Materials & Interfaces·Maria V LomovaMaria N Antipina
Dec 21, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Shiao-Pei S Weathers, Mark R Gilbert
Feb 6, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guojun ChenShaoqin Gong
May 10, 2017·ACS Applied Materials & Interfaces·Fan HuangJianfeng Liu
Jul 8, 2017·ACS Nano·Qi LeiXian-Zheng Zhang
Aug 30, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenwu XiaoYuanpei Li
Mar 1, 2018·ACS Applied Materials & Interfaces·Hyeon-Yeol ChoJeong-Woo Choi
Jan 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li-Li TanYing-Wei Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis