A multi-institutional experience in pediatric high-grade glioma

Frontiers in Oncology
Steve WalstonTerence M Williams

Abstract

Pediatric high-grade gliomas are rare tumors with poor outcomes and incompletely defined management. We conducted a multi-institutional retrospective study to evaluate association of clinical, pathologic, and treatment characteristics with outcomes. Fifty-one patients treated from 1984 to 2008 at the Ohio State University or University of Michigan were included. Histologic subgroups were compared. Log-rank and stepwise Cox proportional hazard modeling were used to analyze progression-free survival (PFS) and overall survival (OS) within the whole group, grade III subgroup, grade IV subgroup, and sub-total resection/biopsy subgroup. Median OS was 27.6 months. Grade III histology, complete tumor resection, and cerebral tumor location correlated with improved PFS and OS. Temozolomide use and chemotherapy after radiotherapy or chemoradiation (CRT) were associated with better PFS while seizure at presentation was associated with better OS. In multivariate analysis, complete resection and chemotherapy following radiotherapy or CRT were independent predictors for improved PFS and OS. For grade III and IV subgroups, complete resection was associated with improved OS (grade III) and seizure presentation was associated with improved OS (g...Continue Reading

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Citations

Jan 16, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hadie AdamsAlfredo Quiñones-Hinojosa
Mar 14, 2018·Cancer Medicine·Meng LiuJohn L Villano
Jan 20, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Amedeo A AziziIrene Slavc
Jun 21, 2019·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Amr MuhammedMohamed S Zaghluol
Jan 29, 2020·Cancer Metastasis Reviews·Christina ColemanSabine Mueller
May 1, 2021·Cancers·Aleksandra NapieralskaMaciej Harat
Dec 12, 2020·Journal of Neurosurgery. Pediatrics·Marcos Devanir Silva da CostaSergio Cavalheiro

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Methods Mentioned

BETA
surgical resection
total resection
surgical
biopsy
imaging techniques

Software Mentioned

SPSS

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