A multi-layered poroelastic slab model under cyclic loading for a single osteon

Biomedical Engineering Online
Yaogeng ChenXing Li

Abstract

An osteon consists of a multi-layered bone matrix and interstitial fluid flow in the lacunar-canalicular system. Loading-induced interstitial fluid flow in the lacunar-canalicular system is critical for osteocyte mechanotransduction and bone remodelling. To investigate the effects of the lamellar structure and heterogeneous material properties of the osteon on the distributions of interstitial fluid flow and seepage velocity, an osteon is idealized as a hollow two-dimensional poroelastic multi-layered slab model subjected to cyclic loading. Based on poroelastic theory, the analytical solutions of interstitial fluid pressure and seepage velocity in lacunar-canalicular pores were obtained. The results show that strain magnitude has a greater influence on interstitial fluid pressure than loading frequency. Interestingly, the heterogeneous distribution of permeability produces remarkable variations in interstitial fluid pressure and seepage velocity in the cross-section of cortical bone. In addition, interstitial fluid flow stimuli to osteocytes are mostly controlled by the value of permeability at the surface of the osteon rather than at the inner wall of the osteon. Interstitial fluid flow induced by cycling loading stimuli to an...Continue Reading

References

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Nov 9, 2007·Biomechanics and Modeling in Mechanobiology·Agnès RémondThibault Lemaire
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Citations

Apr 10, 2021·Journal of Biomechanical Engineering·Nikhil Vivek ShrivasSubham Badhyal
Jun 11, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Theodoor H Smit

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