A multi-platform metabolomics approach demonstrates changes in energy metabolism and the transsulfuration pathway in Chironomus tepperi following exposure to zinc

Aquatic Toxicology
Sara M LongAry A Hoffmann

Abstract

Measuring biological responses in resident biota is a commonly used approach to monitoring polluted habitats. The challenge is to choose sensitive and, ideally, stressor-specific endpoints that reflect the responses of the ecosystem. Metabolomics is a potentially useful approach for identifying sensitive and consistent responses since it provides a holistic view to understanding the effects of exposure to chemicals upon the physiological functioning of organisms. In this study, we exposed the aquatic non-biting midge, Chironomus tepperi, to two concentrations of zinc chloride and measured global changes in polar metabolite levels using an untargeted gas chromatography-mass spectrometry (GC-MS) analysis and a targeted liquid chromatography-mass spectrometry (LC-MS) analysis of amine-containing metabolites. These data were correlated with changes in the expression of a number of target genes. Zinc exposure resulted in a reduction in levels of intermediates in carbohydrate metabolism (i.e., glucose 6-phosphate, fructose 6-phosphate and disaccharides) and an increase in a number of TCA cycle intermediates. Zinc exposure also resulted in decreases in concentrations of the amine containing metabolites, lanthionine, methionine and cys...Continue Reading

References

May 20, 1999·Annual Review of Pharmacology and Toxicology·C D KlaassenS Choudhuri
Feb 3, 2005·Environmental Toxicology and Chemistry·Vincent Pettigrove, Ary Hoffmann
May 14, 2005·Antioxidants & Redox Signaling·Yasoo SugiuraMakoto Suematsu
Dec 16, 2006·The Science of the Total Environment·R PlanellóG Morcillo
Jun 22, 2007·Journal of Applied Toxicology : JAT·Joseph LemireVasu D Appanna
Mar 1, 2008·Ecotoxicology and Environmental Safety·M L BallesterosM A Bistoni
Jan 13, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Adam HinesMark R Viant
Jan 15, 2010·Environmental Pollution·Stephen MarshallAry Hoffmann
Aug 20, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nadine S TaylorMark R Viant
Sep 18, 2010·BMC Evolutionary Biology·Kazuo H TakahashiSiu F Lee
Nov 13, 2010·Environmental Toxicology and Chemistry·Natàlia Garcia-Reyero, Edward J Perkins
Jun 23, 2011·BMC Bioinformatics·Lars-Henrik HeckmannJesper G Sørensen
Sep 2, 2011·Analytical Chemistry·Berin A BoughtonUte Roessner
Sep 17, 2011·Metallomics : Integrated Biometal Science·Sean C BoothRaymond J Turner
Jul 27, 2012·Ecotoxicology and Environmental Safety·Kallie R TownsendAry A Hoffmann
Apr 2, 2013·Metabolomics : Official Journal of the Metabolomic Society·Jianguo XiaDavid S Wishart
Sep 24, 2013·Journal of Proteomics·Elain Gutierrez-CarbonellAna-Flor López-Millán
Sep 1, 1994·Ecotoxicology·M H Depledge, M C Fossi
Mar 8, 2014·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Katherine J JeppeAry A Hoffmann
Mar 19, 2014·Journal of Dairy Science·D HailemariamB N Ametaj

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Citations

Jan 27, 2016·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Vera KovacevicMyrna J Simpson
Jul 31, 2016·Environmental Toxicology and Chemistry·Katherine J JeppeAry A Hoffmann
Apr 4, 2017·Environmental Toxicology and Chemistry·Hung T VuVincent J Pettigrove
Apr 5, 2019·Molecular Medicine·Kim R SimpfendorferRichard A Strugnell
Aug 2, 2019·Metabolomics : Official Journal of the Metabolomic Society·Georgia M SinclairSara M Long

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