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A multi-sample based method for identifying common CNVs in normal human genomic structure using high-resolution aCGH data

PloS One

Nov 11, 2011

Chihyun ParkSanghyun Park

Abstract

It is difficult to identify copy number variations (CNV) in normal human genomic data due to noise and non-linear relationships between different genomic regions and signal intensity. A high-resolution array comparative genomic hybridization (aCGH) containing 42 million probes, which is...read more

Mentioned in this Paper

Chromosomes, Human, Pair 21
Genome-Wide Association Study
Study
Fluctuation
Biologic Segmentation
HapMap
DNA Copy Number Changes
Genome
Nucleic Acid Hybridization Procedure
African Continental Ancestry Group
1
14
Paper Details
References
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  • References49
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A multi-sample based method for identifying common CNVs in normal human genomic structure using high-resolution aCGH data

PloS One

Nov 11, 2011

Chihyun ParkSanghyun Park

PMID: 22073121

DOI: 10.1371/journal.pone.0026975

Abstract

It is difficult to identify copy number variations (CNV) in normal human genomic data due to noise and non-linear relationships between different genomic regions and signal intensity. A high-resolution array comparative genomic hybridization (aCGH) containing 42 million probes, which is...read more

Mentioned in this Paper

Chromosomes, Human, Pair 21
Genome-Wide Association Study
Study
Fluctuation
Biologic Segmentation
HapMap
DNA Copy Number Changes
Genome
Nucleic Acid Hybridization Procedure
African Continental Ancestry Group
1
14

Feeds With Similar Papers

Structural Variation Detection

Structural variations, such as insertions, deletions, inversions, and duplications, are a common feature in human genomes, and a number of studies have reported that such variations are associated with human diseases. Here is the latest research focusing on structural variation detection.


Copy Number Variation

Copy number variation refers to alterations in the number of gene copies or DNA sequences. It can be a duplication, amplification, or a deletion event. Here is the latest research.

Related Papers

Computers in Biology and Medicine

CNV detection method optimized for high-resolution arrayCGH by normality test

Computers in Biology and MedicineJanuary 25, 2012
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IEEE/ACM Transactions on Computational Biology and Bioinformatics

Multisample aCGH data analysis via total variation and spectral regularization

IEEE/ACM Transactions on Computational Biology and BioinformaticsMay 25, 2013
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Paper Details
References
  • References49
  • Citations3
12345
  • References49
  • Citations3
1

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