A multi-scale finite element model for investigation of chondrocyte mechanics in normal and medial meniscectomy human knee joint during walking

Journal of Biomechanics
Petri TanskaRami K Korhonen

Abstract

Mechanical signals experienced by chondrocytes (articular cartilage cells) modulate cell synthesis and cartilage health. Multi-scale modeling can be used to study how forces are transferred from joint surfaces through tissues to chondrocytes. Therefore, estimation of chondrocyte behavior during certain physical activities, such as walking, could provide information about how cells respond to normal and abnormal loading in joints. In this study, a 3D multi-scale model was developed for evaluating chondrocyte and surrounding peri- and extracellular matrix responses during gait loading within healthy and medial meniscectomy knee joints. The knee joint geometry was based on MRI, whereas the input used for gait loading was obtained from the literature. Femoral and tibial cartilages were modeled as fibril-reinforced poroviscoelastic materials, whereas menisci were considered as transversely isotropic. Fluid pressures in the chondrocyte and cartilage tissue increased up to 2MPa (an increase of 30%) in the meniscectomy joint compared to the normal, healthy joint. The elevated level of fluid pressure was observed during the entire stance phase of gait. A medial meniscectomy caused substantially larger (up to 60%) changes in maximum prin...Continue Reading

References

Sep 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J J ParkkinenM Tammi
Jan 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A C HallK A Gehl
May 1, 1990·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M P KadabaM E Wootten
Jul 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J J ParkkinenH J Helminen
May 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·F GuilakV C Mow
Jul 1, 1997·Journal of Anatomy·C A Poole
Jan 27, 1998·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·R T BurksR W Metcalf
Sep 25, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·T M QuinnJ D Sandy
Jan 25, 2002·Biophysical Journal·Farshid GuilakH Ping Ting-Beall
Jul 12, 2002·The New England Journal of Medicine·J Bruce MoseleyNelda P Wray
Jul 16, 2002·Annual Review of Biomedical Engineering·Van C Mow, X Edward Guo
Aug 17, 2002·Biochimica Et Biophysica Acta·Reijo K SironenMikko J Lammi
Oct 11, 2003·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·F ChatainUNKNOWN Société Française d'Arthroscopie
Mar 1, 2006·Biomechanics and Modeling in Mechanobiology·S-K HanW Herzog
Mar 15, 2006·Journal of Biomechanical Engineering·Barbara Zielinska, Tammy L Haut Donahue
Jul 13, 2006·Annals of the New York Academy of Sciences·Farshid GuilakMansoor A Haider
Feb 10, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dong ZhaoBenjamin J Fregly
Mar 16, 2007·Journal of Biomechanics·Diego F VillegasTammy L Haut Donahue
Apr 28, 2007·Journal of Biomechanics·Darryl D D'LimaClifford W Colwell
Mar 11, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Daina L SturnieksDavid G Lloyd
May 23, 2008·Annals of Biomedical Engineering·Ashkan VaziriBashir A Tafti
Sep 12, 2008·The New England Journal of Medicine·Alexandra KirkleyPeter J Fowler
Sep 20, 2008·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·S D MasourosA M J Bull
Nov 4, 2008·The Journal of Bone and Joint Surgery. American Volume·Gillian HawkerPaul Dieppe
Mar 17, 2009·Journal of Orthopaedic Surgery and Research·Guoan LiHarry E Rubash
Apr 29, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Peng-Yuan WangWei-Bor Tsai
Jun 6, 2009·Journal of Biomechanics·Michal KozanekGuoan Li
Jun 10, 2009·Osteoarthritis and Cartilage·D T FelsonUNKNOWN OAI Investigators Group

❮ Previous
Next ❯

Citations

Dec 29, 2015·Osteoarthritis and Cartilage·N H Varady, A J Grodzinsky
Apr 26, 2015·Journal of Biomechanics·Tammy L Haut DonahueSuzanne A Maher
May 6, 2015·Journal of Biomechanics·Tammy Donahue
Aug 18, 2016·Biomechanics and Modeling in Mechanobiology·Naama ShohamAmit Gefen
Mar 21, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Alan J MuellerPeter D Clegg
Aug 12, 2018·Journal of Biomechanical Engineering·Jay C HouGerard A Ateshian
Nov 5, 2017·Journal of Biomechanical Engineering·Mimmi K LiukkonenRami K Korhonen
Nov 28, 2017·Biomechanics and Modeling in Mechanobiology·Petri TanskaRami K Korhonen
Mar 19, 2020·Frontiers in Bioengineering and Biotechnology·Satanik MukherjeeLiesbet Geris
Mar 23, 2020·Computer Methods and Programs in Biomedicine·Ali Zine El-Abidine ArabOsama M Mukdadi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.