A Multi-Target Motor Imagery Training Using Bimodal EEG-fMRI Neurofeedback: A Pilot Study in Chronic Stroke Patients

Frontiers in Human Neuroscience
Giulia LioiChristian Barillot

Abstract

Traditional rehabilitation techniques present limitations and the majority of patients show poor 1-year post-stroke recovery. Thus, Neurofeedback (NF) or Brain-Computer-Interface applications for stroke rehabilitation purposes are gaining increased attention. Indeed, NF has the potential to enhance volitional control of targeted cortical areas and thus impact on motor function recovery. However, current implementations are limited by temporal, spatial or practical constraints of the specific imaging modality used. In this pilot work and for the first time in literature, we applied bimodal EEG-fMRI NF for upper limb stroke recovery on four stroke-patients with different stroke characteristics and motor impairment severity. We also propose a novel, multi-target training approach that guides the training towards the activation of the ipsilesional primary motor cortex. In addition to fMRI and EEG outcomes, we assess the integrity of the corticospinal tract (CST) with tractography. Preliminary results suggest the feasibility of our approach and show its potential to induce an augmented activation of ipsilesional motor areas, depending on the severity of the stroke deficit. Only the two patients with a preserved CST and subcortical l...Continue Reading

References

Nov 27, 1999·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·G Pfurtscheller, F H Lopes da Silva
Feb 24, 2001·IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·H RamoserG Pfurtscheller
May 29, 2004·Cerebral Cortex·Ana SolodkinSteven L Small
Feb 25, 2005·Brain : a Journal of Neurology·Assia JaillardMarc Hommel
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Nikhil SharmaJean-Claude Baron
Dec 7, 2006·Brain : a Journal of Neurology·Cathy M StinearWinston D Byblow
Mar 25, 2008·NeuroImage·Nikhil SharmaJean-Claude Baron
Mar 26, 2011·Journal of Neural Engineering·Moritz Grosse-WentrupKarim Oweiss
Sep 10, 2011·Neurorehabilitation and Neural Repair·Ranganatha SitaramFriedhelm Hummel
Jun 13, 2012·Brain : a Journal of Neurology·Cathy M StinearWinston D Byblow
Mar 27, 2013·Archives of Physical Medicine and Rehabilitation·Michelle L WoodburyPamela W Duncan
Apr 16, 2013·Neuroscience and Biobehavioral Reviews·Sébastien HétuPhilip L Jackson
May 10, 2013·Frontiers in Human Neuroscience·Lynley V BradnamWinston D Byblow
May 15, 2013·Trends in Cognitive Sciences·Niels BirbaumerRanganatha Sitaram
Feb 15, 2014·Stroke; a Journal of Cerebral Circulation·Isabelle FavreAssia Jaillard
Jun 22, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ela B PlowAndre Machado
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Feb 26, 2015·Annals of Neurology·Floriana PichiorriDonatella Mattia
Mar 13, 2015·Frontiers in Behavioral Neuroscience·Maria L BlefariRoger Gassert
Dec 17, 2015·Neurorehabilitation and Neural Repair·Sook-Lei LiewSurjo R Soekadar
Mar 24, 2016·Computer Methods and Programs in Biomedicine·Xia WuXiaotong Wen
Dec 23, 2016·Nature Reviews. Neuroscience·Ranganatha SitaramJames Sulzer
Apr 6, 2017·Frontiers in Neuroscience·Marsel ManoChristian Barillot
May 6, 2017·Frontiers in Human Neuroscience·Lorraine PerronnetChristian Barillot
Jul 6, 2017·Clinical EEG and Neuroscience·Catharina ZichCornelia Kranczioch
Oct 11, 2017·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tianlu WangCeline R Gillebert
Dec 31, 2017·NeuroImage·Robert T ThibaultAmir Raz
May 16, 2018·Annals of Clinical and Translational Neurology·María A CerveraGangadhar Garipelli

❮ Previous
Next ❯

Citations

May 26, 2020·The Cochrane Database of Systematic Reviews·Ruth E BarclayJulie Schubert
Jul 17, 2020·Frontiers in Neuroscience·Epifanio BagarinaoToshiharu Nakai
Jul 14, 2020·Frontiers in Neuroscience·Mathis FleuryAnatole Lécuyer
Jan 15, 2021·Scientific Reports·Justin KilmarxJarrod Lewis-Peacock
Jul 1, 2021·Network Neuroscience·Giulia LioiNicolas Farrugia
Jul 23, 2021·Bulletin of Experimental Biology and Medicine·D D BezmaternykhA V Shurunova

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
SMA

Clinical Trials Mentioned

NCT01677091

Software Mentioned

Psychtoolbox
Brain Products Analyzer
Mensia Modulo
medInria
BrainVision Recview
Matlab
SPM8
GRAPPA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Stroke; a Journal of Cerebral Circulation
Cinzia Calautti, Jean-Claude Baron
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Yonghyun KwonSung Min Son
TheScientificWorldJournal
Gemma H KitsosMark W Parsons
© 2021 Meta ULC. All rights reserved