A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors.

Acta Pharmacologica Sinica
Peng-Xuan RenFang Bai


The COVID-19, caused by SARS-CoV-2, is threatening public health, and there is no effective treatment. In this study, we have implemented a multi-targeted anti-viral drug design strategy to discover highly potent SARS-CoV-2 inhibitors, which simultaneously act on the host ribosome, viral RNA as well as RNA-dependent RNA polymerases, and nucleocapsid protein of the virus, to impair viral translation, frameshifting, replication, and assembly. Driven by this strategy, three alkaloids, including lycorine, emetine, and cephaeline, were discovered to inhibit SARS-CoV-2 with EC50 values of low nanomolar levels potently. The findings in this work demonstrate the feasibility of this multi-targeting drug design strategy and provide a rationale for designing more potent anti-virus drugs.


Jan 22, 2004·Cardiovascular Toxicology·Shujia J Pan, Alan B Combs
Mar 19, 2004·Journal of Medicinal Chemistry·Thomas A HalgrenJay L Banks
Dec 22, 2004·Current Topics in Microbiology and Immunology·D A Brian, R S Baric
Jun 29, 2012·Critical Reviews in Microbiology·Yeping Sun, Po Tien
May 3, 2013·Nature·Andreas M AngerRoland Beckmann
Jun 6, 2013·Virology Journal·Eric BarrowJin Liu
Apr 23, 2014·Nucleic Acids Research·Xavier Robert, Patrice Gouet
Aug 12, 2014·Viruses·Ruth McBrideBurtram C Fielding
Sep 12, 2014·Nature·Nicolas Garreau de LoubresseMarat Yusupov
Feb 28, 2015·Methods in Molecular Biology·Anthony R Fehr, Stanley Perlman
Nov 26, 2015·Antimicrobial Agents and Chemotherapy·Yu GuoYuna Sun
Mar 26, 2016·Trends in Microbiology·Shuo SuGeorge F Gao
Nov 6, 2018·Nucleic Acids Research·UNKNOWN UniProt Consortium
Apr 13, 2019·Nucleic Acids Research·Fábio MadeiraRodrigo Lopez
May 30, 2019·Nature Communications·Robert N Kirchdoerfer, Andrew B Ward
Jan 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jianyi YangDavid Baker
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Feb 23, 2020·The Lancet Infectious Diseases·Ensheng DongLauren Gardner
Mar 3, 2020·The Journal of Infection·Patrick J Lillie The Airborne Hcid Network
Jan 1, 2013·Science China. Chemistry·ZhiFei CaoQuanSheng Zhou
Apr 25, 2020·Cell·Dongwan KimHyeshik Chang
May 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Eugenia Quiros RoldanIsabella Zanella
May 21, 2020·Emerging Microbes & Infections·Ya-Nan ZhangBo Zhang
Jun 18, 2020·Viruses·Aleksandr IanevskiDenis E Kainov
Jun 21, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sean M Cascarina, Eric D Ross
Jul 7, 2020·International Journal of Antimicrobial Agents·Teodoro J OscanoaAndrea Savarino

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