A multiallelic indel in the promoter region of the Cyclin-dependent kinase inhibitor 3 gene is significantly associated with body weight and carcass traits in chickens

Poultry Science
Wenya LiZhuanjian Li

Abstract

Many studies have reported that cyclin-dependent kinase inhibitor 3 (CDKN3) is involved in the cell cycle. However, the function of CDKN3 has not been well elucidated in organisms. In this study, a multiallelic indel caused by a 19-bp fragment and a 2 × 19 bp fragment was shown for the first time to be inserted into the promoter of the CDKN3 gene in 1994 chickens from 9 different breeds. In addition, 6 genotypes (C5C5, C4C4, C3C3, C4C5, C3C4, and C3C5) were observed (C3C3, C4C4, C5C5 have 3 × 19 bp, 4 × 19 bp, and 5 × 19 bp, respectively). Among these genotypes, the C4C4 genotype was the most dominant genotype in 9 breeds. The results of χ2 analysis of CDKN3 gene in different breeds showed that there were significant differences in the distribution of genotypes among different cultivars (P < 0.01). In addition, association study with F2 chicken resource population which produced by Anka and Gushi chickens showed that the C3C4 genotypes had the greatest semi-evisceration weight (SEW, 1163.94 ± 46.84), evisceration weight (EW, 964.15 ± 41.16), head weight (HW, 45.55 ± 1.43), claw weight (CW, 63.42±2.86), wing weight (WW, 129.15±5.48), liver weight (LW, 29.96±1.27), carcass weight (cW, 1286.96±49.53), weight at 10 (1190.68±45.68) ...Continue Reading

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Citations

Mar 18, 2020·Animals : an Open Access Journal From MDPI·Rong FuXiquan Zhang
Apr 17, 2020·Animals : an Open Access Journal From MDPI·Libang HeLei Qu
May 2, 2019·Animal Biotechnology·Yongcai WangGuirong Sun
Feb 28, 2020·Animals : an Open Access Journal From MDPI·Jiayang GaoBao Zhang
Jan 23, 2020·Animals : an Open Access Journal From MDPI·Yi BiXiaoyue Song
Feb 6, 2020·Animals : an Open Access Journal From MDPI·Zhen WangHaijing Zhu
Jan 12, 2021·Frontiers in Cell and Developmental Biology·Xiaohuan ChaoQingbin Luo
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Zhenyu WeiXianyong Lan

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