A multibiomarker risk score helps predict risk for Barrett's esophagus

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Aaron P ThriftHashem B El-Serag

Abstract

Risk prediction models for Barrett's esophagus (BE) have been developed using multiple demographic and clinical variables, but their predictive performance has been modest. Adding a multibiomarker risk score may improve discriminatory ability. We used data from 141 patients with definitive BE and 138 controls participating in a case-control study at the Michael E. DeBakey Veterans Affairs Medical Center (Houston, TX) (97% men, 65% of controls were white, and 89% of cases were white). We derived and compared 3 prediction models. Model 1 included only gastroesophageal reflux disease (GERD) frequency and duration; model 2 included GERD frequency and duration, age, sex, race, waist-to-hip ratio, and Helicobacter pylori status; and model 3 included the variables in model 2 as well as a multibiomarker risk score based on serum levels of interleukin (IL)12p70, IL6, IL8, IL10, and leptin. We assessed their predictive accuracy in terms of discrimination using the area under the receiver operating characteristic curve and calibration analyses. The multibiomarker risk score was associated significantly with risk for BE. Compared with persons with a score of 0, persons with a score of 3 or higher had a greater than 10-fold increased risk f...Continue Reading

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Citations

Feb 7, 2016·Cancer Epidemiology·Aaron P Thrift
Nov 28, 2015·Digestive Diseases and Sciences·Seiji ShiotaAaron P Thrift
Feb 11, 2015·Journal of Medical Microbiology·Behrooz Mozaffari naminMohammad Mehdi Soltan Dallal
Jun 7, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bradley J KendallAaron P Thrift
Oct 19, 2016·Digestive Diseases and Sciences·Nicholas R CrewsPrasad G Iyer
Jul 29, 2016·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·Anna K Brandtner, Michael Quante
Mar 7, 2015·Best Practice & Research. Clinical Gastroenterology·Jennifer L Schneider, Douglas A Corley
Mar 17, 2017·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Aaron P ThriftHashem B El-Serag
Dec 18, 2016·Asian Journal of Surgery·Fang-Liang Huang, Sheng-Jie Yu
Oct 17, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·A KahnF C Ramirez
May 10, 2016·World Journal of Gastrointestinal Pharmacology and Therapeutics·Irene MartinucciSantino Marchi
Jan 14, 2018·Current Treatment Options in Gastroenterology·Sarmed S Sami, Prasad G Iyer
Apr 6, 2019·Alimentary Pharmacology & Therapeutics·Andrew T KunzmannHelen G Coleman
May 11, 2019·Alimentary Pharmacology & Therapeutics·Tarek Sawas, David A Katzka
Jun 9, 2016·Current Opinion in Gastroenterology·Aaron P Thrift
May 2, 2018·Digestive Diseases and Sciences·Fouad Otaki, Prasad G Iyer
Jun 16, 2015·World Journal of Gastroenterology : WJG·Magnus HallandPrasad G Iyer
May 28, 2019·Nature Reviews. Disease Primers·Yonne PetersPeter D Siersema
Apr 20, 2018·Digestive Diseases and Sciences·Aaron P Thrift
Nov 4, 2015·The American Journal of Gastroenterology·Nicholas J ShaheenUNKNOWN American College of Gastroenterology
Nov 11, 2020·International Journal of Molecular Sciences·Ming-Ling ChangSien-Sing Yang
Apr 15, 2015·Deutsches Ärzteblatt International·Joachim LabenzArnulf H Hölscher
Feb 20, 2021·Nature Reviews. Gastroenterology & Hepatology·Aaron P Thrift
Nov 21, 2020·Gastrointestinal Endoscopy Clinics of North America·Michael B Cook, Aaron P Thrift
Jun 17, 2021·The American Journal of Gastroenterology·Sarmed S SamiPrasad G Iyer
Nov 4, 2021·Nature Reviews. Gastroenterology & Hepatology·Melissa SchmidtTrevor A Graham

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