Abstract
To validate, in a multicenter clinical trial, the performance of biomarkers and algorithms for differential diagnosis in a population of women diagnosed with an unknown ovarian cyst or pelvic tumor. Six hospitals in Western Sweden consecutively enrolled 638 women from September 2013 to February 2016. Serum, transvaginal ultrasound data, and basic patient characteristics were collected preoperatively. Biomarker levels, risk of malignancy algorithm (ROMA), and risk of malignancy index (RMI) were calculated and compared with the final pathology report. Our sample of 638 patients had 445 benign, 31 borderline, and 162 malignant tumors recorded, and the overall incidence of epithelial ovarian cancer was 21%. In postmenopausal women, RMI (>200), ROMA (≥29.9), CA125 (>35 U/mL), and HE4 (>140 pmol/L) showed sensitivity at 89%, 91%, 92%, and 72%, respectively, and specificity at 80%, 77%, 80%, and 92%. In premenopausal women, sensitivity of RMI, ROMA (≥11.6), CA125, and HE4 (>70 pmol/L) was 87%, 87%, 96%, and 83%, respectively, and specificity was 90%, 81%, 60%, 91%. Diagnostic accuracy (ROC AUC) of RMI and ROMA in postmenopausal women was 0.85 and 0.84, and in premenopausal women, 0.90 and 0.81. Our results suggest that CA125 is superi...Continue Reading
References
Oct 1, 1990·British Journal of Obstetrics and Gynaecology·I JacobsJ G Grudzinskas
Nov 3, 1993·Journal of the National Cancer Institute·R P WoolasR C Bast
Aug 1, 1996·British Journal of Obstetrics and Gynaecology·S TingulstadK Nustad
Feb 15, 2001·Current Opinion in Obstetrics & Gynecology·U Menon, I J Jacobs
Aug 3, 2005·Gynecologic Oncology·Daniel G RosenRobert C Bast
Dec 14, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R C BastK Lu
Dec 13, 2006·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A P M HeintzU Beller
Mar 22, 2007·Cancer·John R van NagellRichard J Kryscio
Dec 7, 2007·Disease Markers·Donna Badgwell, Robert C Bast
Dec 7, 2007·Gynecologic Oncology·Richard G MooreRobert C Bast
Jul 1, 2008·Gynecologic Oncology·Laura J HavrileskyAndrew Berchuck
Sep 5, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kimberly A LoweCharles W Drescher
Oct 15, 2008·Gynecologic Oncology·Richard G MooreSteven J Skates
Feb 4, 2009·Cancer·Andreas du BoisJacobus Pfisterer
Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
May 18, 2010·American Journal of Obstetrics and Gynecology·Richard G MooreSteven J Skates
Feb 10, 2011·British Journal of Cancer·T Van GorpI Vergote
Mar 23, 2011·Gynecologic Oncology·Francis JacobViola Heinzelmann-Schwarz
Jan 10, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Toon Van GorpIgnace Vergote
Jan 17, 2012·Journal of Gynecologic Oncology·Karolina PartheenKarin Sundfeldt
Jun 21, 2012·BMC Cancer·Fake LiMing Chen
Jul 28, 2012·Gynecologic Oncology·Mona Aarenstrup KarlsenEstrid V S Høgdall
Dec 12, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·JiaYing LinVoramon Sangvatanakul
Aug 24, 2013·Obstetrics and Gynecology·Edward J PavlikJohn R van Nagell
Jan 15, 2014·Gynecologic Oncology·A StiekemaC M Korse
Mar 15, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiwen WangJun Qi
Nov 21, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·György SölétormosRaphael Molina
Jan 24, 2016·Gynecologic Oncology·Cesare RomagnoloMassimo Gion
May 21, 2016·Gynecologic and Obstetric Investigation·Marut YanaranopBandit Thinkhamrop
May 31, 2016·Gynecologic Oncology·Pernilla Dahm-KählerLiza Johannesson
Jul 16, 2016·ELife·Yuxuan WangBert Vogelstein
Oct 26, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Farshid DayyaniMatthew Schlumbrecht
Sep 8, 2016·Oman Medical Journal·Khawla Al MusalhiWaad-Allah Mula-Abed
Mar 8, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Phyllis GlancSteven R Goldstein
Mar 23, 2018·Science Translational Medicine·Yuxuan WangNickolas Papadopoulos
Citations
Nov 6, 2018·Journal of Ovarian Research·Michal MigdaMarek Maleńczyk
Jan 25, 2020·Journal of Clinical Medicine·Maria LyckeKarin Sundfeldt
Jun 27, 2019·Communications Biology·Stefan EnrothUlf Gyllensten
Jul 16, 2020·Journal of Cellular and Molecular Medicine·Mingyang BaoYueqing Hu
Oct 15, 2019·Frontiers in Cell and Developmental Biology·Alka SinghManisha Sachan
Feb 14, 2020·Journal of Ovarian Research·Li-Yuan FengLi Li
May 28, 2020·Cancers·Se Ik KimYong Sang Song
Sep 2, 2020·Cancers·Ulf GyllenstenStefan Enroth
Sep 4, 2020·Journal of Medical Case Reports·Chanil Deshan EkanayakeSachini Rasnayake
Nov 19, 2019·Disease Markers·Zhiheng WangChunmei Ying
Apr 27, 2020·Current Drug Targets·Khalid El BairiMariam Amrani
Dec 24, 2019·Heliyon·Thingreila MuinaoMintu Pal
Jan 12, 2020·Communications Biology·Stefan EnrothUlf Gyllensten
Mar 23, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F GkrozouM Paschopoulos
Sep 14, 2019·Talanta·B SzymańskaE Gorodkiewicz
Apr 12, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A SrivastavaS Patidar
Apr 2, 2021·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D TimmermanC Fotopoulou
Jun 12, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Dirk TimmermanChristina Fotopoulou
Jun 11, 2021·Facts, Views & Vision in ObGyn·D TimmermanC Fotopoulou
Aug 14, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Maria LyckeKarin Sundfeldt
Aug 29, 2021·Scientific Reports·Arpita SuriSanjiv Kumar Bansal