PMID: 16645457Apr 29, 2006Paper

A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management

Anesthesiology
Anita HoldcroftSimon Thompson

Abstract

Cannabinoids have dose-related antinociceptive effects in animals. This clinical study aimed to investigate whether a single oral dose of cannabis plant extract (Cannador; Institute for Clinical Research, IKF, Berlin, Germany) could provide pain relief with minimal side effects for postoperative pain. Patients (aged 18-75 yr) were recruited and consented before surgery if patient-controlled analgesia was planned for provision of postoperative pain relief. Each patient received a single dose of 5, 10, or 15 mg Cannador if he or she had at least moderate pain after stopping patient-controlled analgesia. Starting with 5 mg, dose escalation was based on the number of patients requesting rescue analgesia and adverse effects. Pain relief, pain intensity, and side effects were recorded over 6 h and analyzed using tests for trend with dose. Rescue analgesia was requested by all 11 patients (100%) receiving 5 mg, 15 of 30 patient (50%) receiving 10 mg, and 6 of 24 patients (25%) receiving 15 mg Cannador (log rank test for trend in time to rescue analgesia with dose P < 0.001). There were also significant trends across the escalating dose groups for decreasing pain intensity at rest (P = 0.01), increasing sedation (P = 0.03), and more ad...Continue Reading

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References

Jul 1, 1975·Clinical Pharmacology and Therapeutics·R NoyesA C Canter
Sep 1, 1975·Clinical Pharmacology and Therapeutics·N L Benowitz, R T Jones
Mar 1, 1989·Controlled Clinical Trials·R Simon
Jan 1, 1985·Statistics in Medicine·J Cuzick
Aug 1, 1981·Journal of Clinical Pharmacology·A K JainG Smith
May 1, 1997·Anaesthesia·A HoldcroftF Evans
Nov 26, 1997·Anaesthesia·A Holdcroft
Nov 7, 1998·BMJ : British Medical Journal·D G Altman
Nov 27, 1998·European Journal of Pharmacology·R MechoulamV Di Marzo
Aug 26, 1999·Life Sciences·J M WalkerK Tsou
Apr 29, 2000·Prostaglandins & Other Lipid Mediators·G KunosJ A Wagner
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·A M MalfaitM Feldmann
Oct 2, 2003·JAMA : the Journal of the American Medical Association·Matthias KarstUdo Schneider
Feb 28, 2004·European Journal of Pain : EJP·N AttalD Bouhassira
Jul 9, 2004·Life Sciences·Sumner H BursteinRobert B Zurier
Sep 1, 2001·Expert Review of Neurotherapeutics·A Holdcroft, P Patel

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Citations

Apr 17, 2013·European Journal of Clinical Pharmacology·Arno Hazekamp, Eibert R Heerdink
Jan 24, 2009·Wiener medizinische Wochenschrift·Rita Lenk, Rudolf Likar
Jun 25, 2013·Zebrafish·Muhammad T AkhtarMichael K Richardson
Jun 3, 2008·British Journal of Anaesthesia·R D Hosking, J P Zajicek
Jun 1, 2011·British Journal of Anaesthesia·I Power
May 29, 2009·Nursing·Clifford Gevirtz
Sep 25, 2007·American Journal of Therapeutics·Bill H McCarberg, Robert L Barkin
Jan 12, 2012·Clinical and Experimental Pharmacology & Physiology·Jarkko KalliomäkiMärta Segerdahl
Sep 14, 2006·Pharmacological Reviews·Pál PacherGeorge Kunos
Jun 19, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Tongtong WangMark A Ware
Oct 12, 2007·Drugs·Josée GuindonPierre Beaulieu
Dec 15, 2010·Drugs·Matthias KarstJörg Ahrens
Sep 18, 2007·Current Opinion in Anaesthesiology·Pierre Beaulieu, Mark Ware
Feb 1, 2007·Anesthesiology·Pierre Beaulieu
Mar 6, 2009·Current Opinion in Supportive and Palliative Care·W Paul Farquhar-Smith
May 14, 2014·Expert Opinion on Pharmacotherapy·Marjan de VriesHarry van Goor
Sep 18, 2007·Expert Review of Neurotherapeutics·Paul F Smith
Feb 25, 2009·Expert Opinion on Investigational Drugs·Matthias Karst, Sonja Wippermann
Jun 16, 2010·Drug Development and Industrial Pharmacy·Kalpana S PaudelAudra L Stinchcomb
Jan 30, 2007·Current Medical Research and Opinion·Michael IskedjianThomas R Einarson
Nov 3, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frederike K EngelsJaap Verweij
Oct 26, 2007·Pharmacology & Therapeutics·Hui-Lin PanDe-Pei Li
Dec 20, 2007·The Journal of Pain : Official Journal of the American Pain Society·Sanjeet NarangRobert N Jamison
Sep 2, 2015·Current Pain and Headache Reports·Bjorn JensenMark Wallace
Nov 6, 2014·American Journal of Therapeutics·Chrysoula C StachtariDimitrios G Vasilakos
Jan 17, 2017·Acta Anaesthesiologica Scandinavica·A J Stevens, M D Higgins
Dec 3, 2009·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Sandro Cinti
Mar 26, 2011·Chronic Respiratory Disease·Elspeth E PickeringAnita Holdcroft
Oct 24, 2017·Journal of Cutaneous Medicine and Surgery·Gurbir Dhadwal, Mark G Kirchhof
Oct 7, 2017·Current Rheumatology Reports·E Alfonso Romero-SandovalP Abigail Alvarado-Vázquez
Apr 17, 2018·Fundamental & Clinical Pharmacology·Régis BouquiéPascale Jolliet
Apr 22, 2009·Revista brasileira de anestesiologia·Laura BonfáNúbia Verçosa de Figueiredo
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tuba EsfandyariAlan R Zinsmeister
Mar 7, 2008·The International Journal of Neuroscience·Mohammad Reza JafariBijan Djahanguiri
Apr 3, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zaid H MaayahJason R B Dyck
May 31, 2020·Regional Anesthesia and Pain Medicine·Faraj W AbdallahRichard Brull
May 31, 2020·Regional Anesthesia and Pain Medicine·Jennifer D MeekerEdward R Mariano

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