A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infection

The Pediatric Infectious Disease Journal
Adriano ArguedasMaria Paris

Abstract

Given the relatively high prevalence of recurrent and persistent acute otitis media (AOM) and the prominent etiologic role of Streptococcus pneumoniae, especially penicillin-nonsusceptible strains in children with these conditions, new alternative treatments are desirable. Children 6 months-4 years of age with AOM considered to be at risk for recurrent or persistent infection received large dosage cefdinir 25 mg/kg oral suspension once daily for 10 days. Children were evaluated pretreatment (day 1), on therapy (days 4-6), end of therapy (days 12-14) and at follow-up (days 25-28). All children had tympanocentesis at enrollment. In culture-positive children, tympanocentesis was repeated after 3-5 days (days 4-6) unless evidence of absence of middle ear effusion was documented. Of 447 children enrolled, 230 were clinically and bacteriologically evaluable (74% 2 years old or younger; 57% treated for AOM in previous 3 months). Bacteriologic eradication, based on repeat tympanocentesis on days 4-6, was achieved in 74% (170 of 230) of children; 76% (201 of 266) of AOM pathogens were eradicated. Eradication of penicillin-susceptible, -intermediate and -resistant S. pneumoniae was 91% (50 of 55), 67% (18 of 27) and 43% (10 of 23), respe...Continue Reading

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Citations

Aug 30, 2008·Journal of General Internal Medicine·Joy Chen, Jawad Ahmad
Apr 16, 2009·Current Infectious Disease Reports·Timothy F Murphy
Jun 16, 2005·International Journal of Pediatric Otorhinolaryngology·Nili SegalAlberto Leiberman
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Nov 26, 2009·The Pediatric Infectious Disease Journal·Eugene LeibovitzRon Dagan
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Jun 16, 2017·Current Otorhinolaryngology Reports·Anna Granath
Mar 31, 2017·The New England Journal of Medicine·Michael E Pichichero

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